Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
and protein synthesis [70]. The antitumor activity of Act D has been reported to be attenuated by polyamines, such as spermine, but if a polyamine inhibitor such as methyl glyoxal-bis(guanylhydrazone) (MGBG ...
. Study . # Patients . Dose . CR(%) . PR(%) . Remarks . Newlands [19] GBM AA Ph-I Rec 3 200 i.v.; 5/28 d † 0 (0) 2 (67) “Dramatic clinical improvement” reported. Brock [ 20 ] GBM AA Ph-I Rec 17 75 p.o.; 7 wks ...
in overall survival between the groups. However, according to the available data, paclitaxel and doxorubicin appear to have similar antitumor activity . Partial responses (PR) were seen in 20 % of patients who ...
↑; p53↑; Bcl-XL↓ [106] Huh- 7 cells 0, 7.5, 15 and 20 μm Caspase-9↓; Bcl-2↓; PARP↓ [122] HSC-T6 cells 5 mg/ml Fas↑; Bax↑; Bcl-xL↓ [173] HepG2 cells 1, 3, 5, 10 and 20 μg/ml Proteasome activator complex ...
camptothecin analog Irinotecan (CPT-11), a DNA topoisomerase I inhibitor, which requires conversion to the active metabolite SN-38 in order to exert antitumor efficacy. This conversion is catalyzed ...
endogenous PGDS expression), the restoration of PGDS expression levels in A172 cells resulted in a 20 % reduction in the rate of cell growth measured after 7 days. The overexpression of PGDS in A172 cells also ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!