Suspensory ligament degeneration associated with pituitary pars intermedia dysfunction in horses

Suspensory ligament degeneration associated with pituitary pars intermedia dysfunction in horses Suspensory ligament (SL) degeneration leads to fetlock hyperextension and is common in several breeds of horses ( Halper et al., 2006 ). Horses with pituitary pars intermedia dysfunction (PPID) also frequently present with fetlock hyperextension. A similar association between Achilles tendon rupture and Cushing's disease in humans has been documented ( Mousa et al., 1999 ). In humans, corticosteroid treatment is regarded as a risk factor for Achilles tendinopathy due to a reduction in tensile strength ( Haraldsson et al., 2006 ).</P>Although cortisol concentrations are not consistently elevated in horses with PPID ( Tadros and Frank, 2013 ), degeneration of the SL may also be associated with long term exposure to intermittently high cortisol levels. Some horses with advanced PPID develop transient diabetes mellitus when stress and systemic disease are encountered ( Tadros and Frank, 2013 ). Diabetes mellitus is also a risk factor for human tendinopathy ( de Oliveira et al., 2013 ). Insulin resistance (IR) has been documented in Peruvian Paso horses with degenerative SL desmitis (DSLD); thus, IR is a possible cause of DSLD ( Xie et al., 2011 ). The aim of the present study was to determine whether the SLs of horses with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Veterinary Journal Elsevier

Suspensory ligament degeneration associated with pituitary pars intermedia dysfunction in horses

Loading next page...
 
/lp/elsevier/suspensory-ligament-degeneration-associated-with-pituitary-pars-8C9GU06H7b
Publisher
Elsevier
Copyright
Copyright © 2014 Elsevier Ltd
ISSN
1090-0233
D.O.I.
10.1016/j.tvjl.2014.12.037
Publisher site
See Article on Publisher Site

Abstract

Suspensory ligament (SL) degeneration leads to fetlock hyperextension and is common in several breeds of horses ( Halper et al., 2006 ). Horses with pituitary pars intermedia dysfunction (PPID) also frequently present with fetlock hyperextension. A similar association between Achilles tendon rupture and Cushing's disease in humans has been documented ( Mousa et al., 1999 ). In humans, corticosteroid treatment is regarded as a risk factor for Achilles tendinopathy due to a reduction in tensile strength ( Haraldsson et al., 2006 ).</P>Although cortisol concentrations are not consistently elevated in horses with PPID ( Tadros and Frank, 2013 ), degeneration of the SL may also be associated with long term exposure to intermittently high cortisol levels. Some horses with advanced PPID develop transient diabetes mellitus when stress and systemic disease are encountered ( Tadros and Frank, 2013 ). Diabetes mellitus is also a risk factor for human tendinopathy ( de Oliveira et al., 2013 ). Insulin resistance (IR) has been documented in Peruvian Paso horses with degenerative SL desmitis (DSLD); thus, IR is a possible cause of DSLD ( Xie et al., 2011 ). The aim of the present study was to determine whether the SLs of horses with

Journal

The Veterinary JournalElsevier

Published: Mar 1, 2015

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off