Carbohydrate Polymers 181 (2018) 659–667 Contents lists available at ScienceDirect Carbohydrate Polymers journal homepage: www.elsevier.com/locate/carbpol Surfactant-stable and pH-sensitive liposomes coated with N-succinyl- chitosan and chitooligosaccharide for delivery of quercetin Joon Seob Seong, Mid Eum Yun, Soo Nam Park Department of Fine Chemistry, Cosmetic R&D Center, Cosmetic Industry Coupled Collaboration Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea ARTICLE I NFO ABSTRACT Keywords: Layer-by-layer (LbL) self-assembly of multilayered liposomes is used to improve the stability of conventional Layer-by-layer liposomes. In this study, the LbL technology was used to prepare novel multilayered liposomes from chit- Liposome ooligosaccharide and N-succinyl-chitosan. We propose that this preparation can be used as a transdermal drug N-succinyl-chitosan delivery system (TDDS) to enhance stability against surfactants and control drug release. Particle size increased Surfactant-stable with the number of layers in the multilayer and the zeta potential varied between positive and negative values pH-sensitive with alternate deposition of polyelectrolytes. Finally, approximately 300–400 nm-thick four-layered liposomes Quercetin were prepared. These liposomes were more stable against surfactants and showed a relatively high release of quercetin at pH 5.5 than the uncoated liposomes as assessed via in vitro drug release and skin permeation
Carbohydrate Polymers – Elsevier
Published: Feb 1, 2018
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