Journal of Colloid and Interface Science 516 (2018) 384–391 Contents lists available at ScienceDirect Journal of Colloid and Interface Science journal homepage: www.elsevier.com/locate/jcis Regular Article Surface phosphorylation of nanoparticles by hexokinase: A powerful tool for cellular uptake improvement a,b a a a,⇑ Imran Nazir , Christina Leichner , Bao Le-Vinh , Andreas Bernkop-Schnürch Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria Department of Pharmacy, COMSATS Institute of Information Technology, 22010 Abbottabad, Pakistan graphical a bstract ar ti c l e i nf o ab stra ct Article history: The aim of the study was to develop zeta potential changing nanoparticles (NPs) via surface phosphory- Received 20 November 2017 lation in order to improve their uptake by epithelial cells. Polymeric NPs were formed via in situ gelation Revised 22 January 2018 between chitosan (CS) and chondroitin sulphate (ChS). Phosphorylation of these NPs was carried out by Accepted 23 January 2018 using hexokinase. The resulting phosphorylated NPs (p-NPs) were characterized in respect of their size Available online 31 January 2018 and zeta potential. Phosphate release was quantiﬁed by incubating the particles with isolated as well as cell-associated intestinal alkaline
Journal of Colloid and Interface Science – Elsevier
Published: Apr 15, 2018
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