Available online at www.sciencedirect.com ScienceDirect Surface functionalization and dynamics of polymeric cell culture substrates 1 2 2,4 John D Krutty , Samantha K Schmitt , Padma Gopalan and 1,2,3 William L Murphy The promise of growing tissues to replace or improve the such as growth factors, and the extracellular matrix function of failing ones, a practice often referred to as (ECM), which is tissue-speciﬁc and consists of insoluble regenerative medicine, has been driven in recent years by the proteins and glycosaminoglycans. Evidence in the last development of stem cells and cell lines. Stem cells are decade suggests that the properties of the insoluble typically cultured outside the body to increase cell number or microenvironment can guide cell behaviors such as adhe- differentiate the cells into mature cell types. In order to sion, proliferation, morphology and differentiation maximize the regenerative potential of these cells, there is a [1,2,3,4]. The combination of these soluble and insoluble need to understand cell–material interactions that direct cell signals regulates cell behavior [5,6]. While insoluble behavior and cell–material dynamics. Most synthetic surfaces matrix components can be derived from animal sources, used for growth and differentiation of cells in the lab are clinical application of stem
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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