Available online at www.sciencedirect.com ScienceDirect Surface functionalization and dynamics of polymeric cell culture substrates 1 2 2,4 John D Krutty , Samantha K Schmitt , Padma Gopalan and 1,2,3 William L Murphy The promise of growing tissues to replace or improve the such as growth factors, and the extracellular matrix function of failing ones, a practice often referred to as (ECM), which is tissue-speciﬁc and consists of insoluble regenerative medicine, has been driven in recent years by the proteins and glycosaminoglycans. Evidence in the last development of stem cells and cell lines. Stem cells are decade suggests that the properties of the insoluble typically cultured outside the body to increase cell number or microenvironment can guide cell behaviors such as adhe- differentiate the cells into mature cell types. In order to sion, proliferation, morphology and differentiation maximize the regenerative potential of these cells, there is a [1,2,3,4]. The combination of these soluble and insoluble need to understand cell–material interactions that direct cell signals regulates cell behavior [5,6]. While insoluble behavior and cell–material dynamics. Most synthetic surfaces matrix components can be derived from animal sources, used for growth and differentiation of cells in the lab are clinical application of stem
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera