Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery Recent progress in gene transfer technology enables the delivery of genes precisely to the application-relevant cell type ex vivo on cultivated primary cells or in vivo on local or systemic administration. Gene vectors based on lentiviruses or adeno-associated viruses can be engineered such that they use a cell surface marker of choice for cell entry instead of their natural receptors. Binding to the surface marker is mediated by a targeting ligand displayed on the vector particle surface, which can be a peptide, single-chain antibody, or designed ankyrin repeat protein. Examples include vectors that deliver genes to specialized endothelial cells or lymphocytes, tumor cells, or particular cells of the nervous system with potential applications in gene function studies and molecular medicine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Trends in Biotechnology Elsevier

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

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Publisher
Elsevier Current Trends
Copyright
Copyright © 2015 Elsevier Ltd
ISSN
0167-7799
D.O.I.
10.1016/j.tibtech.2015.09.008
Publisher site
See Article on Publisher Site

Abstract

Recent progress in gene transfer technology enables the delivery of genes precisely to the application-relevant cell type ex vivo on cultivated primary cells or in vivo on local or systemic administration. Gene vectors based on lentiviruses or adeno-associated viruses can be engineered such that they use a cell surface marker of choice for cell entry instead of their natural receptors. Binding to the surface marker is mediated by a targeting ligand displayed on the vector particle surface, which can be a peptide, single-chain antibody, or designed ankyrin repeat protein. Examples include vectors that deliver genes to specialized endothelial cells or lymphocytes, tumor cells, or particular cells of the nervous system with potential applications in gene function studies and molecular medicine.

Journal

Trends in BiotechnologyElsevier

Published: Dec 1, 2015

References

  • Chimeric antigen receptor therapy for cancer
    Barrett, D.M.
  • Gene therapy on the move
    Kaufmann, K.B.
  • Lentiviral vectors with measles virus glycoproteins – dream team for gene transfer?
    Buchholz, C.J.
  • In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
    Swiech, L.
  • Selection and evaluation of clinically relevant AAV variants in a xenograft liver model
    Lisowski, L.
  • Targeted transduction of CD34+ hematopoietic progenitor cells in nonpurified human mobilized peripheral blood mononuclear cells
    Liang, M.
  • Efficient targeted transduction of primary human endothelial cells with dual-targeted lentiviral vectors
    Pariente, N.
  • Engineering adeno-associated virus serotype 2-based targeting vectors using a new insertion site-position 453-and single point mutations
    Boucas, J.
  • Isolation of targeted AAV2 vectors from novel virus display libraries
    Waterkamp, D.A.
  • Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter
    Cronin, T.

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