Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate

Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated... •Two fCSs with well-repeated units but minor difference in sulfation pattern were investigated.•Both fCS-Ib and fCS-Pg could significantly improve the lipid profile of HFFD mice.•fCS-Pg was more effective in lowering blood TC, LDL and AI levels.•Both fCSs obviously lowered serum glucose and increased hepatic glycogen synthesis.•Both fCSs might be potential antihyperlipdemic drugs with liver protection effect. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Carbohydrate Polymers Elsevier

Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0144-8617
D.O.I.
10.1016/j.carbpol.2016.03.013
Publisher site
See Article on Publisher Site

Abstract

•Two fCSs with well-repeated units but minor difference in sulfation pattern were investigated.•Both fCS-Ib and fCS-Pg could significantly improve the lipid profile of HFFD mice.•fCS-Pg was more effective in lowering blood TC, LDL and AI levels.•Both fCSs obviously lowered serum glucose and increased hepatic glycogen synthesis.•Both fCSs might be potential antihyperlipdemic drugs with liver protection effect.

Journal

Carbohydrate PolymersElsevier

Published: Aug 20, 2016

References

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