Substrate fiber alignment mediates tendon cell response to inflammatory signaling

Substrate fiber alignment mediates tendon cell response to inflammatory signaling Acta Biomaterialia 71 (2018) 306–317 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Substrate fiber alignment mediates tendon cell response to inflammatory signaling a,b a,b,c a,b a,b a,b,⇑ Angelina D. Schoenenberger , Jasper Foolen , Pascal Moor , Unai Silvan , Jess G. Snedeker Department of Orthopedics, Balgrist Hospital, University of Zurich, Zurich, Switzerland Institute for Biomechanics, ETH Zurich, Zurich, Switzerland Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands ar ti c l e i nf o ab stra ct Article history: Healthy tendon tissue features a highly aligned extracellular matrix that becomes disorganized with dis- Received 12 December 2017 ease. Recent evidence suggests that inflammation coexists with early degenerative changes in tendon, Received in revised form 14 February 2018 and that crosstalk between immune-cells and tendon fibroblasts (TFs) can contribute to poor tissue heal- Accepted 1 March 2018 ing. We hypothesized that a disorganized tissue architecture may predispose tendon cells to degenerative Available online 10 March 2018 extracellular matrix remodeling pathways, particularly within a pro-inflammatory niche. This hypothesis was tested by analyzing human TFs cultured on electrospun polycaprolactone (PCL) mats with either Keywords: highly aligned or randomly oriented fiber structures. We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biomaterialia Elsevier

Substrate fiber alignment mediates tendon cell response to inflammatory signaling

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Publisher
Elsevier
Copyright
Copyright © 2018 Acta Materialia Inc.
ISSN
1742-7061
eISSN
1878-7568
D.O.I.
10.1016/j.actbio.2018.03.004
Publisher site
See Article on Publisher Site

Abstract

Acta Biomaterialia 71 (2018) 306–317 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Substrate fiber alignment mediates tendon cell response to inflammatory signaling a,b a,b,c a,b a,b a,b,⇑ Angelina D. Schoenenberger , Jasper Foolen , Pascal Moor , Unai Silvan , Jess G. Snedeker Department of Orthopedics, Balgrist Hospital, University of Zurich, Zurich, Switzerland Institute for Biomechanics, ETH Zurich, Zurich, Switzerland Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands ar ti c l e i nf o ab stra ct Article history: Healthy tendon tissue features a highly aligned extracellular matrix that becomes disorganized with dis- Received 12 December 2017 ease. Recent evidence suggests that inflammation coexists with early degenerative changes in tendon, Received in revised form 14 February 2018 and that crosstalk between immune-cells and tendon fibroblasts (TFs) can contribute to poor tissue heal- Accepted 1 March 2018 ing. We hypothesized that a disorganized tissue architecture may predispose tendon cells to degenerative Available online 10 March 2018 extracellular matrix remodeling pathways, particularly within a pro-inflammatory niche. This hypothesis was tested by analyzing human TFs cultured on electrospun polycaprolactone (PCL) mats with either Keywords: highly aligned or randomly oriented fiber structures. We

Journal

Acta BiomaterialiaElsevier

Published: Apr 15, 2018

References

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