Acta Biomaterialia 71 (2018) 306–317 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Substrate ﬁber alignment mediates tendon cell response to inﬂammatory signaling a,b a,b,c a,b a,b a,b,⇑ Angelina D. Schoenenberger , Jasper Foolen , Pascal Moor , Unai Silvan , Jess G. Snedeker Department of Orthopedics, Balgrist Hospital, University of Zurich, Zurich, Switzerland Institute for Biomechanics, ETH Zurich, Zurich, Switzerland Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands ar ti c l e i nf o ab stra ct Article history: Healthy tendon tissue features a highly aligned extracellular matrix that becomes disorganized with dis- Received 12 December 2017 ease. Recent evidence suggests that inﬂammation coexists with early degenerative changes in tendon, Received in revised form 14 February 2018 and that crosstalk between immune-cells and tendon ﬁbroblasts (TFs) can contribute to poor tissue heal- Accepted 1 March 2018 ing. We hypothesized that a disorganized tissue architecture may predispose tendon cells to degenerative Available online 10 March 2018 extracellular matrix remodeling pathways, particularly within a pro-inﬂammatory niche. This hypothesis was tested by analyzing human TFs cultured on electrospun polycaprolactone (PCL) mats with either Keywords: highly aligned or randomly oriented ﬁber structures. We
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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