Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse

Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse In the present study, we studied drug effects of Ca 2+ antagonists on the retinal degeneration of rd mouse to evaluate their efficacy. Several kinds of Ca 2+ antagonists, diltiazem, nicardipine, nilvadipine or nifedipine were administrated intraperitoneally and thereafter retinal morphology and functions were analyzed. In addition, we performed DNA microarray analysis both in nilvadipine treated and control retinas to understand their drug effects at molecular levels. We found that nilvadipine caused significant preservation of retinal thickness in rd mouse during the initial stage of the retinal degeneration, and nicardipine showed also significant but lesser preservation than nilvadipine. However, we recognized no preservation effects of diltiazem and nifedipine. In the total 3774 genes, the expressions of 27 genes were altered upon administration of nilvadipine, including several genes related to the apoptotic pathway, neuro-survival factor, Ca 2+ metabolisms, and other mechanisms. It is suggested that some types of Ca 2+ channel blockers, such as nilvadipine and nicardipine, are able to preserve photoreceptor cells in rd mouse and can potentially be used to treat some RP patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochemical and Biophysical Research Communications Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Inc.
ISSN
0006-291x
D.O.I.
10.1016/j.bbrc.2003.12.034
Publisher site
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Abstract

In the present study, we studied drug effects of Ca 2+ antagonists on the retinal degeneration of rd mouse to evaluate their efficacy. Several kinds of Ca 2+ antagonists, diltiazem, nicardipine, nilvadipine or nifedipine were administrated intraperitoneally and thereafter retinal morphology and functions were analyzed. In addition, we performed DNA microarray analysis both in nilvadipine treated and control retinas to understand their drug effects at molecular levels. We found that nilvadipine caused significant preservation of retinal thickness in rd mouse during the initial stage of the retinal degeneration, and nicardipine showed also significant but lesser preservation than nilvadipine. However, we recognized no preservation effects of diltiazem and nifedipine. In the total 3774 genes, the expressions of 27 genes were altered upon administration of nilvadipine, including several genes related to the apoptotic pathway, neuro-survival factor, Ca 2+ metabolisms, and other mechanisms. It is suggested that some types of Ca 2+ channel blockers, such as nilvadipine and nicardipine, are able to preserve photoreceptor cells in rd mouse and can potentially be used to treat some RP patients.

Journal

Biochemical and Biophysical Research CommunicationsElsevier

Published: Jan 23, 2004

References

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