In coincidence with the spread of HIV infection, 1 tuberculosis is today amongst the universal health threats. Approximately 13 million new cases of tuberculosis each year worldwide; about one fifth of them are in India. 2 In 2011, there were an estimated 8.7 million new cases of TB and 1.4 million people died from TB. TB is one of the top killers of women, with 5,00,000 deaths among HIV women in 2011. India, China, the Russian Federation and South Africa have almost 60% of the world’s cases of MDR-TB. 3 It is estimated that nearly 5,00,000 people die from the disease—more than 1000 per day. 5 As resistant strains of Mycobacterium tuberculosis (MTB) have slowly emerged, treatment failure is a main reality. 4 However, various drugs such as streptomycin (i), rifampicin (ii), pyrazinamide (iii), isoniazid (iv), ethionamide (v) and ethambutol (vi) etc ( Fig. 1 ) are used for the treatment of TB. Since, these are taking six month long time treatment, 6 therefore it becomes imperative for the discovery of some new chemical entity.</P>In the recent past, several benzo[ h ]quinazoline derivatives have been reported to exhibit antiplatelet combined with anti-inflammatory activity, 7 antimicrobial activity, 8 as
Bioorganic & Medicinal Chemistry Letters – Elsevier
Published: Nov 1, 2013
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