Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes

Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes •Small self-cleaving ribozymes are essential for rolling-circle-based replication of satellite and pathogenic RNAs.•Structure–function research on active site alignments and catalytic mechanisms of the Rbz hammerhead ribozyme is described.•Pre-catalytic conformations of newly-identified pistol, twister and twister–sister ribozymes are described.•There is currently a divergence of views as to the cleavage site alignments and catalytic mechanisms adopted by twister and twister–sister ribozymes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Chemical Biology Elsevier

Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
1367-5931
D.O.I.
10.1016/j.cbpa.2017.09.017
Publisher site
See Article on Publisher Site

Abstract

•Small self-cleaving ribozymes are essential for rolling-circle-based replication of satellite and pathogenic RNAs.•Structure–function research on active site alignments and catalytic mechanisms of the Rbz hammerhead ribozyme is described.•Pre-catalytic conformations of newly-identified pistol, twister and twister–sister ribozymes are described.•There is currently a divergence of views as to the cleavage site alignments and catalytic mechanisms adopted by twister and twister–sister ribozymes.

Journal

Current Opinion in Chemical BiologyElsevier

Published: Dec 1, 2017

References

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