Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO)

Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme... Bioorganic & Medicinal Chemistry Letters 28 (2018) 1024–1029 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO) a,1 a,1 a a a b Dongdong Liang , Elizabeth Robinson , Kellie Hom , Wenbo Yu , Nam Nguyen , Yue Li , c a,⇑ a,⇑ Qianshou Zong , Angela Wilks , Fengtian Xue Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States Department of Chemistry and Biochemistry, University of Maryland College Park, College Park 20740, United States College of Biological and Chemical Sciences and Engineering, Jiaxing University, Jiaxing City, Zhejiang 314001, People’s Republic of China ar ti c l e i nf o ab stra ct Article history: Received 12 January 2018 2018 Elsevier Ltd. All rights reserved. Revised 3 February 2018 Accepted 13 February 2018 Available online 14 February 2018 21–23 Introduction drive the metabolic flux of heme into the cell. Furthermore, the P. aeruginosa DhemO isogenic mutant, or a strain comple- Pseudomonas aeruginosa is an opportunistic Gram-negative bac- mented with a non-functional pa-HemO, showed significant atten- terial and one of the most common causes http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO)

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.02.027
Publisher site
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Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1024–1029 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO) a,1 a,1 a a a b Dongdong Liang , Elizabeth Robinson , Kellie Hom , Wenbo Yu , Nam Nguyen , Yue Li , c a,⇑ a,⇑ Qianshou Zong , Angela Wilks , Fengtian Xue Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States Department of Chemistry and Biochemistry, University of Maryland College Park, College Park 20740, United States College of Biological and Chemical Sciences and Engineering, Jiaxing University, Jiaxing City, Zhejiang 314001, People’s Republic of China ar ti c l e i nf o ab stra ct Article history: Received 12 January 2018 2018 Elsevier Ltd. All rights reserved. Revised 3 February 2018 Accepted 13 February 2018 Available online 14 February 2018 21–23 Introduction drive the metabolic flux of heme into the cell. Furthermore, the P. aeruginosa DhemO isogenic mutant, or a strain comple- Pseudomonas aeruginosa is an opportunistic Gram-negative bac- mented with a non-functional pa-HemO, showed significant atten- terial and one of the most common causes

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

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