Bioorganic & Medicinal Chemistry Letters 28 (2018) 1024–1029 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO) a,1 a,1 a a a b Dongdong Liang , Elizabeth Robinson , Kellie Hom , Wenbo Yu , Nam Nguyen , Yue Li , c a,⇑ a,⇑ Qianshou Zong , Angela Wilks , Fengtian Xue Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States Department of Chemistry and Biochemistry, University of Maryland College Park, College Park 20740, United States College of Biological and Chemical Sciences and Engineering, Jiaxing University, Jiaxing City, Zhejiang 314001, People’s Republic of China ar ti c l e i nf o ab stra ct Article history: Received 12 January 2018 2018 Elsevier Ltd. All rights reserved. Revised 3 February 2018 Accepted 13 February 2018 Available online 14 February 2018 21–23 Introduction drive the metabolic ﬂux of heme into the cell. Furthermore, the P. aeruginosa DhemO isogenic mutant, or a strain comple- Pseudomonas aeruginosa is an opportunistic Gram-negative bac- mented with a non-functional pa-HemO, showed signiﬁcant atten- terial and one of the most common causes
Bioorganic & Medicinal Chemistry Letters – Elsevier
Published: Apr 1, 2018
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