002&3908(95)00109-3 Neuropharmacology Vol. 34, No. 10, pp. 1219-1237, 1995 Copyright 0 1995 Elsevier Science Ltd Printed in Great Britain. All rights reserved 0028-3908/95 $29.50 + 0.00 Review: Neurotransmitter Receptors VIII Structure and Function of the NMDA Channel Receptor Department of Pharmacology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113, Japan (Accepted 3 July 1995) Glutamate receptor (GluR) channels play major roles in fast excitatory synaptic transmission. Based on the pharmacological properties, GluR channels have been classified into three maijor subtypes, that is, the cc-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) receptor channels. Among them, the NMDA receptor channel is the most clearly defined subtype due to the development of highly selective ligands such as NMDA (Watkins, 1962) and D-2-amino-5-phosphonovalerate (APV) (Davies et al., 1981). Studies with these agonists and antagonists revealed unique properties and important physiological roles of the NMDA receptor channel. The NMDA receptor channel differs in fundamental ways from the non-NMDA receptor channels, and these properties relate directly to its physiological roles. The NMDA receptor channel is gated in a unique manner both by ligands and by voltage. The voltage dependence is caused by Mg*+ block within the ion channel (Mayer et
Neuropharmacology – Elsevier
Published: Oct 1, 1995
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