Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of... Bioorganic & Medicinal Chemistry 26 (2018) 2928–2936 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com/locate/bmc Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-b-lactamases a a a,1 a,2 a,c,3 Dong Zhang , Marios S. Markoulides , Dmitrijs Stepanovs , Anna M. Rydzik , Ahmed El-Hussein , a,4 a a,5 b a Corentin Bon , Jos J.A.G. Kamps , Klaus-Daniel Umland , Patrick M. Collins , Samuel T. Cahill , a b,d,e a a a,⇑ David Y. Wang , Frank von Delft , Jürgen Brem , Michael A. McDonough , Christopher J. Schofield Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom The National Institute of Laser Enhanced Science, Cairo University, Egypt Structural Genomics Consortium (SGC), University of Oxford, Oxford, OX3 7DQ, UK Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa ar ti c l e i nf o ab stra ct Article history: Metallo-b-lactamases (MBLs) enable bacterial resistance to almost all classes of b-lactam antibiotics. We Received 29 January 2018 report studies on enethiol containing MBL inhibitors, which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2018 The Authors
ISSN
0968-0896
D.O.I.
10.1016/j.bmc.2018.02.043
Publisher site
See Article on Publisher Site

Abstract

Bioorganic & Medicinal Chemistry 26 (2018) 2928–2936 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com/locate/bmc Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-b-lactamases a a a,1 a,2 a,c,3 Dong Zhang , Marios S. Markoulides , Dmitrijs Stepanovs , Anna M. Rydzik , Ahmed El-Hussein , a,4 a a,5 b a Corentin Bon , Jos J.A.G. Kamps , Klaus-Daniel Umland , Patrick M. Collins , Samuel T. Cahill , a b,d,e a a a,⇑ David Y. Wang , Frank von Delft , Jürgen Brem , Michael A. McDonough , Christopher J. Schofield Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom The National Institute of Laser Enhanced Science, Cairo University, Egypt Structural Genomics Consortium (SGC), University of Oxford, Oxford, OX3 7DQ, UK Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa ar ti c l e i nf o ab stra ct Article history: Metallo-b-lactamases (MBLs) enable bacterial resistance to almost all classes of b-lactam antibiotics. We Received 29 January 2018 report studies on enethiol containing MBL inhibitors, which

Journal

Bioorganic & Medicinal ChemistryElsevier

Published: Jul 15, 2018

References

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