Bioorganic & Medicinal Chemistry 26 (2018) 2928–2936 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry journal homepage: www.elsevier.com/locate/bmc Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-b-lactamases a a a,1 a,2 a,c,3 Dong Zhang , Marios S. Markoulides , Dmitrijs Stepanovs , Anna M. Rydzik , Ahmed El-Hussein , a,4 a a,5 b a Corentin Bon , Jos J.A.G. Kamps , Klaus-Daniel Umland , Patrick M. Collins , Samuel T. Cahill , a b,d,e a a a,⇑ David Y. Wang , Frank von Delft , Jürgen Brem , Michael A. McDonough , Christopher J. Schoﬁeld Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansﬁeld Road, Oxford OX1 3TA, United Kingdom Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom The National Institute of Laser Enhanced Science, Cairo University, Egypt Structural Genomics Consortium (SGC), University of Oxford, Oxford, OX3 7DQ, UK Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa ar ti c l e i nf o ab stra ct Article history: Metallo-b-lactamases (MBLs) enable bacterial resistance to almost all classes of b-lactam antibiotics. We Received 29 January 2018 report studies on enethiol containing MBL inhibitors, which
Bioorganic & Medicinal Chemistry – Elsevier
Published: Jul 15, 2018
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