Structural and functional modeling of viral protein 5 of Infectious Bursal Disease Virus

Structural and functional modeling of viral protein 5 of Infectious Bursal Disease Virus Virus Research 247 (2018) 55–60 Contents lists available at ScienceDirect Virus Research journal homepage: www.elsevier.com/locate/virusres Structural and functional modeling of viral protein 5 of Infectious Bursal Disease Virus Bhaskar Ganguly , Sunil Kumar Rastogi Animal Biotechnology Center, Department of Veterinary Physiology and Biochemistry, College of Veterinary and Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India ARTICLE I NFO ABSTRACT Keywords: Infectious Bursal Disease (IBD) is an acute, highly contagious and immunosuppressive disease of young chicken. Infectious bursal disease virus The causative virus (IBDV) is a bi-segmented, double-stranded RNA virus. The virus encodes five major proteins, Viral protein 5 viral protein (VP) 1–5. VPs 1–3 have been characterized crystallographically. Albeit a rise in the number of Function studies reporting successful heterologous expression of VP5 in recent times, challenging the notion that rapid In silico death of host cells overexpressing VP5 disallows obtaining sufficiently pure preparations of the protein for Structure crystallographic studies, the structure of VP5 remains unknown and its function controversial. Our study de- scribes the first 3D model of IBD VP5 obtained through an elaborate computational workflow. Based on the results of the study, IBD VP5 can be predicted to be a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Structural and functional modeling of viral protein 5 of Infectious Bursal Disease Virus

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2018.01.017
Publisher site
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Abstract

Virus Research 247 (2018) 55–60 Contents lists available at ScienceDirect Virus Research journal homepage: www.elsevier.com/locate/virusres Structural and functional modeling of viral protein 5 of Infectious Bursal Disease Virus Bhaskar Ganguly , Sunil Kumar Rastogi Animal Biotechnology Center, Department of Veterinary Physiology and Biochemistry, College of Veterinary and Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India ARTICLE I NFO ABSTRACT Keywords: Infectious Bursal Disease (IBD) is an acute, highly contagious and immunosuppressive disease of young chicken. Infectious bursal disease virus The causative virus (IBDV) is a bi-segmented, double-stranded RNA virus. The virus encodes five major proteins, Viral protein 5 viral protein (VP) 1–5. VPs 1–3 have been characterized crystallographically. Albeit a rise in the number of Function studies reporting successful heterologous expression of VP5 in recent times, challenging the notion that rapid In silico death of host cells overexpressing VP5 disallows obtaining sufficiently pure preparations of the protein for Structure crystallographic studies, the structure of VP5 remains unknown and its function controversial. Our study de- scribes the first 3D model of IBD VP5 obtained through an elaborate computational workflow. Based on the results of the study, IBD VP5 can be predicted to be a

Journal

Virus ResearchElsevier

Published: Mar 2, 2018

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