Virus Research 247 (2018) 55–60 Contents lists available at ScienceDirect Virus Research journal homepage: www.elsevier.com/locate/virusres Structural and functional modeling of viral protein 5 of Infectious Bursal Disease Virus Bhaskar Ganguly , Sunil Kumar Rastogi Animal Biotechnology Center, Department of Veterinary Physiology and Biochemistry, College of Veterinary and Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India ARTICLE I NFO ABSTRACT Keywords: Infectious Bursal Disease (IBD) is an acute, highly contagious and immunosuppressive disease of young chicken. Infectious bursal disease virus The causative virus (IBDV) is a bi-segmented, double-stranded RNA virus. The virus encodes ﬁve major proteins, Viral protein 5 viral protein (VP) 1–5. VPs 1–3 have been characterized crystallographically. Albeit a rise in the number of Function studies reporting successful heterologous expression of VP5 in recent times, challenging the notion that rapid In silico death of host cells overexpressing VP5 disallows obtaining suﬃciently pure preparations of the protein for Structure crystallographic studies, the structure of VP5 remains unknown and its function controversial. Our study de- scribes the ﬁrst 3D model of IBD VP5 obtained through an elaborate computational workﬂow. Based on the results of the study, IBD VP5 can be predicted to be a
Virus Research – Elsevier
Published: Mar 2, 2018
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