•Thymidine kinase (TK) mutants of herpes simplex virus type 1 were generated.•Activity to bromodeoxyuridine (BrdU), acyclovir and deoxythymidine was evaluated.•Seven resistance-related amino acid substitutions resulted in no activity to BrdU.•Eleven natural gene polymorphisms led to high activity to BrdU.•The N244H mutant protein was verified as TK with altered substrate specificity.
Journal of Virological Methods – Elsevier
Published: Sep 1, 2017
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