Squid photoreceptor terminals synthesize calexcitin, a learning related protein

Squid photoreceptor terminals synthesize calexcitin, a learning related protein Nerve endings of squid photoreceptor neurons generate large synaptosomes upon homogenization of the optic lobe. Using several independent methods, these presynaptic structures have been shown to synthesize a wealth of soluble, cytoskeletal and nuclear encoded mitochondrial proteins, and to account for essentially all the translation activity of the synaptosomal fraction. We are now presenting evidence that calexcitin, a learning related, Ca 2+ -binding protein of the B photoreceptors of Hermissenda crassicornis (a mollusk), is synthesized and subjected to post-translational modifications in the squid photoreceptor terminals. In view of the essential role of presynaptic protein synthesis in long-term memory formation in Aplysia, our data suggest that a comparable role may be played by calexcitin synthesized in the squid photoreceptor terminals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Squid photoreceptor terminals synthesize calexcitin, a learning related protein

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Ltd
ISSN
0304-3940
D.O.I.
10.1016/S0304-3940(03)00593-7
Publisher site
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Abstract

Nerve endings of squid photoreceptor neurons generate large synaptosomes upon homogenization of the optic lobe. Using several independent methods, these presynaptic structures have been shown to synthesize a wealth of soluble, cytoskeletal and nuclear encoded mitochondrial proteins, and to account for essentially all the translation activity of the synaptosomal fraction. We are now presenting evidence that calexcitin, a learning related, Ca 2+ -binding protein of the B photoreceptors of Hermissenda crassicornis (a mollusk), is synthesized and subjected to post-translational modifications in the squid photoreceptor terminals. In view of the essential role of presynaptic protein synthesis in long-term memory formation in Aplysia, our data suggest that a comparable role may be played by calexcitin synthesized in the squid photoreceptor terminals.

Journal

Neuroscience LettersElsevier

Published: Aug 14, 2003

References

  • Active polysomes in the axoplasm of the squid giant axon
    Giuditta, A.; Menichini, E.; Perrone Capano, C.; Langella, M.; Martin, R.; Castigli, E.; Kaplan, B.B.
  • Biochemistry of molluscan learning and memory
    Nelson, T.J.; Alkon, D.L.

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