THE JOURNAL OF PEDIATRICS � www.jpeds.com INSIGHTS AND IMAGES Spontaneous Regression of a Recalcitrant Wart after Bivalent Papillomavirus Vaccination 10-year-old girl presented with a wart located on the 2 structural proteins (L1 and L2). In addition to an immune right ﬁnger of her hand that had appeared 9 months response to the L1 capsid protein, a nonspeciﬁc effect related A before (Figure, A). It hadbeenrefractorytomul- to locally released chemokines could also be involved. HPV vac- tiple topical treatments used, including cryotherapy (6 ses- cination may be a useful option for the management of some sions), salicylic acid, and cantharidin. Ten days after receiving recalcitrant warts in prepubertal girls. ■ the ﬁrst dose of the human papillomavirus (HPV) bivalent vaccine, total remission of the wart was noted (Figure, B). Jose M. Martin,MD, PhD Regression of common warts has been reported anecdot- Department of Dermatology ally after the administration of both tetravalent and bivalent Hospital Clinico Universitario 1-5 vaccines against speciﬁc HPV. The bivalent vaccine was au- Department of Medicine thorized for immunization against HPV types 16 and 18, and University of Valencia it is indicated in patients from years of age 9 onward for the prevention of premalignant cervical, vulvar,
The Journal of Pediatrics – Elsevier
Published: Mar 1, 2018
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