Specification of neuronal fates in the ventral neural tube

Specification of neuronal fates in the ventral neural tube The generation of distinct classes of neurons at defined positions is a fundamental step in the development of the vertebrate central nervous system. Recent work has begun to reveal the extracellular signals and transcriptional mediators that direct the pattern of generation of distinct neuronal subtypes in the neural tube. This work has provided a framework to understand the patterning of the ventral neural tube and is permitting molecular analyses of the assembly of functional neuronal circuits. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Neurobiology Elsevier

Specification of neuronal fates in the ventral neural tube

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Ltd
ISSN
0959-4388
DOI
10.1016/S0959-4388(00)00172-0
Publisher site
See Article on Publisher Site

Abstract

The generation of distinct classes of neurons at defined positions is a fundamental step in the development of the vertebrate central nervous system. Recent work has begun to reveal the extracellular signals and transcriptional mediators that direct the pattern of generation of distinct neuronal subtypes in the neural tube. This work has provided a framework to understand the patterning of the ventral neural tube and is permitting molecular analyses of the assembly of functional neuronal circuits.

Journal

Current Opinion in NeurobiologyElsevier

Published: Feb 1, 2001

References

  • Gradual refinement of activin-induced thresholds requires protein synthesis
    Papin, C; Smith, JC
  • Conservation of neurogenic genes and mechanisms
    Chan, YM; Jan, YN
  • Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
    Sommer, L; Ma, Q; Anderson, DJ

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