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its SH3 domains , to the carboxy- terminal proline-rich regions of the guanine nucleotide exchange factor Sos. Here we report the synthesis and solution structure of the amino- terminal SH3 domain of GRB2 ...
of the Grb2 –Gab1 signaling complex is driven via a bivalent interaction through the binding of the C‐ terminal homology 3 (cSH3) domain within each monomer of Grb2 homodimer to two distinct RXXK motifs, herein ...
. Mueller. 1997. Solution structure of the Grb2 N - terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts. J. Mol ...
, and other algorithms. The Grb2 protein consists of a central SH2 domain flanked by two SH3 domains (www.rcsb.org). The binding specificity of the Grb2 N - terminal SH3 ( N - SH3 ) domain have been studied in detail ...
of the N - terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos. Nature Structural Biol 1994;1:898-907. 32. Lim WA, Richards FM, Fox RO. Structural determinants of peptide-binding ...
), followed by a color development reagent. Construction of GST fusion proteins and antibodies The GST–Lck- SH3 and GST–HS1- SH3 fusion proteins have been described (11). The GST– Grb2 N - terminal SH3 and C ...
, and metastasis [6–8]. Tks5 is a scaffolding protein with an amino terminal phox homology (PX) domain , five Src homology 3 ( SH3 ) domains , and several proline-rich motifs [4, 9]. The PX domain accounts for the lipid ...
-terminus participates in assembly of the cytoplasmic capping complex . (A) The organization of vertebrate CE is shown with the N - terminal triphosphatase domain indicated in white, the guanylyltransferase ...
(Ringstad et al., 1997). Another survey using Paircoil (Berger et al., 1995) revealed that the presence of an N - terminal coiled-coil domain and a C- terminal SH3 domain was consistent among all SH3 -containing ...
is required for transforming [21] and diglyceride-stimulated exchange [39] activities; and a potential SH3 -binding site (IPPPPG). Domain /sites N - Terminal Region and Potential Role of Vav in Transcriptional ...
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