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by EMBO (ALTF 701-2013). The authors declare no potential conflict of interest. human pluripotent stem cells, X chromosome inactivation , skewed methylation , XIST , histone marks, long-term culture ...
. , Saitou M. , Giorgetti L. , Heard E. , Schulz E.G. ( 2017 ) Two coupled feedback loops explain random mono-allelic Xist upregulation at the onset of X - chromosome inactivation . BioXRIV. 10.1101/204909. 25 ...
regulate initiation of X chromosome inactivation (XCI) in mouse embryonic stem cells (mESCs). Xist levels are low in undifferentiated mESCs before onset of XCI, because of pluripotency transcription factors ...
mutagenesis and transgenesis in mouse embryonic stem cells (ESCs) and in mice. Deletion of the Xist gene results in skewed inactivation of the wild type X chromosome , indicating that this locus is essential ...
transcriptional silencing and DNA methylation (Hendrich et al., 1997). In KS, the inactivation to a large extent of supernumerary X chromosome (s) is commonly observed. In particular, the possibility of a skewed ...
not be informative. Allelic difference in Xist RNA splicing efficiency is associated with nonrandom Xist induction Although largely random, differentiation-induced X chromosome inactivation can be skewed (35 ...
embryos. This imprinted X chromosome inactivation (iXCI) depends on expression and spreading in cis of the Xist noncoding RNA on the Xp [8]. X -encoded RNF12 is a known and important XCI trans activator ...
be increased if X inactivation were highly skewed , such that one of the parental X chromosomes was expressed in relatively few cells. The more extreme the skew in thymic cells (specifically, the dendritic cells ...
with respect to its putative influence on the phenotype. In principal, the parental origin of the X chromosome , gene-dosage effects in conjunction with (possibly skewed ) X chromosome inactivation , and—especially ...
- 43 ) Google Scholar Crossref Search ADS PubMed WorldCat 21 Bolduc V , Chagnon P , Provost S , et al. No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans ...
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