Simultaneous determination of Vitamin A, 25-hydroxyl vitamin D3 α-tocopherol in small biological fluids by liquid chromatography-tandem mass spectrometry

Simultaneous determination of Vitamin A, 25-hydroxyl vitamin D3 α-tocopherol in small biological... •Representative indicators of fat soluble vitamins in the guidelines for medical diagnosis and treatment drafted by the Ministry of health could be simultaneously detection, suitable for the detection of fat soluble vitamins deficiencies.•This method with small sample volume lowers the probability of invalid detection because of insufficient sample size, which makes it an important application potential in pediatrics and other clinical examination.•Batched optimized pretreatment for sample could transferred into automatic operation easily.•μElution plate was used to lower the sample volume and simplify sample processing. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Chromatography B Elsevier

Simultaneous determination of Vitamin A, 25-hydroxyl vitamin D3 α-tocopherol in small biological fluids by liquid chromatography-tandem mass spectrometry

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
1570-0232
eISSN
1873-376X
D.O.I.
10.1016/j.jchromb.2017.12.017
Publisher site
See Article on Publisher Site

Abstract

•Representative indicators of fat soluble vitamins in the guidelines for medical diagnosis and treatment drafted by the Ministry of health could be simultaneously detection, suitable for the detection of fat soluble vitamins deficiencies.•This method with small sample volume lowers the probability of invalid detection because of insufficient sample size, which makes it an important application potential in pediatrics and other clinical examination.•Batched optimized pretreatment for sample could transferred into automatic operation easily.•μElution plate was used to lower the sample volume and simplify sample processing.

Journal

Journal of Chromatography BElsevier

Published: Mar 15, 2018

References

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