•WT mice have robust tactile allodynia and thermal hyperalgesia after STZ treatment.•STZ treatment promoted the distribution of HMGB1 into cytoplasm.•STZ-induced peripheral neuropathy was modest in Sigma-1R−/− mice.•STZ treatment did not alter the levels of HMGB1 in DRG from Sigma-1R−/− mice.•Sigma-1R-mediated HMGB1 expression is critical in type 1 diabetes.
Neuroscience Letters – Elsevier
Published: Mar 6, 2018
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