Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain

Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of... •WT mice have robust tactile allodynia and thermal hyperalgesia after STZ treatment.•STZ treatment promoted the distribution of HMGB1 into cytoplasm.•STZ-induced peripheral neuropathy was modest in Sigma-1R−/− mice.•STZ treatment did not alter the levels of HMGB1 in DRG from Sigma-1R−/− mice.•Sigma-1R-mediated HMGB1 expression is critical in type 1 diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain

Loading next page...
 
/lp/elsevier/sigma-1-receptor-mediated-hmgb1-expression-in-spinal-cord-is-involved-lq0jYA0uxk
Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0304-3940
D.O.I.
10.1016/j.neulet.2018.02.002
Publisher site
See Article on Publisher Site

Abstract

•WT mice have robust tactile allodynia and thermal hyperalgesia after STZ treatment.•STZ treatment promoted the distribution of HMGB1 into cytoplasm.•STZ-induced peripheral neuropathy was modest in Sigma-1R−/− mice.•STZ treatment did not alter the levels of HMGB1 in DRG from Sigma-1R−/− mice.•Sigma-1R-mediated HMGB1 expression is critical in type 1 diabetes.

Journal

Neuroscience LettersElsevier

Published: Mar 6, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Access to DeepDyve database
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off