Sialic acid-triggered macroscopic properties switching on a smart polymer surface

Sialic acid-triggered macroscopic properties switching on a smart polymer surface Article history: Constructing smart surfaces with responsive polymers capable of dynamically and reversibly chang- Received 1 May 2017 ing their chemical and physical properties by responding to the recognition of biomolecules remains a Received in revised form 21 August 2017 challenging task. And, the key to achieving this purpose relies on the design of polymers to precisely Accepted 23 August 2017 interact with the target molecule and successfully transform the interaction signal into tunable macro- Available online 26 August 2017 scopic properties, further achieve special bio-functions. Herein, inspired by carbohydrate–carbohydrate interaction (CCI) in life system, we developed a three-component copolymer poly(NIPAAm-co-PT-co- Keywords: Glc) bearing a binding unit glucose (Glc) capable of recognizing sialic acid, a type of important molecular Smart polymer targets for cancer diagnosis and therapy, and reported the sialic acid triggered macroscopic properties Sialic acid switching on this smart polymer surface. Detailed mechanism studies indicated that multiple hydrogen Interface bonding interactions between Glc unit and Neu5Ac destroyed the initial hydrogen bond network of the Wettability copolymer, leading to a reversible “contraction-to-swelling” conformational transition of the copolymer chains, accompanied with distinct macroscopic property switching (i.e., surface wettability, morphol- ogy, stiffness) of the copolymer film. And these features enabled http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Surface Science Elsevier

Sialic acid-triggered macroscopic properties switching on a smart polymer surface

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0169-4332
eISSN
1873-5584
D.O.I.
10.1016/j.apsusc.2017.08.150
Publisher site
See Article on Publisher Site

Abstract

Article history: Constructing smart surfaces with responsive polymers capable of dynamically and reversibly chang- Received 1 May 2017 ing their chemical and physical properties by responding to the recognition of biomolecules remains a Received in revised form 21 August 2017 challenging task. And, the key to achieving this purpose relies on the design of polymers to precisely Accepted 23 August 2017 interact with the target molecule and successfully transform the interaction signal into tunable macro- Available online 26 August 2017 scopic properties, further achieve special bio-functions. Herein, inspired by carbohydrate–carbohydrate interaction (CCI) in life system, we developed a three-component copolymer poly(NIPAAm-co-PT-co- Keywords: Glc) bearing a binding unit glucose (Glc) capable of recognizing sialic acid, a type of important molecular Smart polymer targets for cancer diagnosis and therapy, and reported the sialic acid triggered macroscopic properties Sialic acid switching on this smart polymer surface. Detailed mechanism studies indicated that multiple hydrogen Interface bonding interactions between Glc unit and Neu5Ac destroyed the initial hydrogen bond network of the Wettability copolymer, leading to a reversible “contraction-to-swelling” conformational transition of the copolymer chains, accompanied with distinct macroscopic property switching (i.e., surface wettability, morphol- ogy, stiffness) of the copolymer film. And these features enabled

Journal

Applied Surface ScienceElsevier

Published: Jan 1, 2018

References

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