Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task Recent studies on apolipoprotein E (apoE) have stressed the importance of this protein in neuronal viability, especially in the hippocampal area. In the present study, we used the Morris water maze to asess spatial learning and memory in 6-month-old homozygous apoE-deficient and heterozygous control mice. The apoE status was checked by genotyping and immunocytochemistry. ApoE-knockout mice were not able to learn the task at all, developed neither spatial nor other strategies to locate the platform, but rather an unusual repetitive behavioral pattern of ‘wall bumping’. Heterozygous control mice did not experience any difficulty with the task. Swimming ability and general locomotor activity of both groups were comparable. These results indicate that absence of apoE in these animals might be critical for spatial learning and memory abilities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Ltd
ISSN
0006-8993
D.O.I.
10.1016/S0006-8993(96)01448-5
Publisher site
See Article on Publisher Site

Abstract

Recent studies on apolipoprotein E (apoE) have stressed the importance of this protein in neuronal viability, especially in the hippocampal area. In the present study, we used the Morris water maze to asess spatial learning and memory in 6-month-old homozygous apoE-deficient and heterozygous control mice. The apoE status was checked by genotyping and immunocytochemistry. ApoE-knockout mice were not able to learn the task at all, developed neither spatial nor other strategies to locate the platform, but rather an unusual repetitive behavioral pattern of ‘wall bumping’. Heterozygous control mice did not experience any difficulty with the task. Swimming ability and general locomotor activity of both groups were comparable. These results indicate that absence of apoE in these animals might be critical for spatial learning and memory abilities.

Journal

Brain ResearchElsevier

Published: Mar 28, 1997

References

  • Structural changes accompanying memory storage
    Baily, C.H.; Kandel, E.R.
  • Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
    Gordon, I.; Grauer, E.; Genis, I.; Schayek, E.; Michaelson, D.M.
  • Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerve
    Leblanc, A.C.; Poduslo, J.E.
  • Neurodegeneration in the central nervous system of apoE-deficient mice
    Masliah, E.; Mallory, M.; Ge, N.; Alford, M.; Veinbergs, I.; Roses, A.D.
  • Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions
    Schenk, F.; Morris, R.G.M.

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