Serum level of long noncoding RNA H19 as a diagnostic biomarker of multiple myeloma

Serum level of long noncoding RNA H19 as a diagnostic biomarker of multiple myeloma Circulating long noncoding RNA (lncRNA) H19 has been reported to be a biomarker for cancer monitoring. The purpose of this study was to determine whether serum lncRNA could serve as a novel biomarker for the diagnosis of multiple myeloma (MM) and evaluate its value of clinical application. In our study, the expression of lncRNA H19 was up-regulated in 80 patients with MM and MM cell lines by RT-PCR analysis. Clinicopathological analysis showed the expression level of H19 could assist clinical staging, and the severity of the disease could be roughly determined according to the amount of H19 expressed in the patient serum. This is the first report to show that H19 was expressed in the serum of MM patients, suggesting that upregulation of serum lncRNA H19 may prove to be a novel biomarker for early diagnosis and clinical treatment of MM. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinica Chimica Acta Elsevier

Serum level of long noncoding RNA H19 as a diagnostic biomarker of multiple myeloma

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0009-8981
eISSN
1873-3492
D.O.I.
10.1016/j.cca.2018.02.019
Publisher site
See Article on Publisher Site

Abstract

Circulating long noncoding RNA (lncRNA) H19 has been reported to be a biomarker for cancer monitoring. The purpose of this study was to determine whether serum lncRNA could serve as a novel biomarker for the diagnosis of multiple myeloma (MM) and evaluate its value of clinical application. In our study, the expression of lncRNA H19 was up-regulated in 80 patients with MM and MM cell lines by RT-PCR analysis. Clinicopathological analysis showed the expression level of H19 could assist clinical staging, and the severity of the disease could be roughly determined according to the amount of H19 expressed in the patient serum. This is the first report to show that H19 was expressed in the serum of MM patients, suggesting that upregulation of serum lncRNA H19 may prove to be a novel biomarker for early diagnosis and clinical treatment of MM.

Journal

Clinica Chimica ActaElsevier

Published: May 1, 2018

References

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