Serotonin (5-HT) 2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

Serotonin (5-HT) 2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not... The novel, preferential 5-HT 2C receptor agonist, Ro 60-0175 (( S )-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine) (2.5 mg/kg, s.c.), markedly suppressed dialysate levels of dopamine (DA) and noradrenaline (NA) levels in the frontal cortex of freely-moving rats without affecting levels of 5-HT. In contrast, the novel and selective 5-HT 2C receptor antagonist, SB-242084 (6-chloro-5-methyl-1-(6-(2-methylpyridin-3-yloxy) pyridin-3-yl carbamoyl) indoline) (10.0 mg/kg, i.p.), markedly increased dialysate levels of DA and NA without modifying those of 5-HT. These data suggest that 5-HT 2C receptors exert a tonic, inhibitory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuropharmacology Elsevier

Serotonin (5-HT) 2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

Neuropharmacology, Volume 37 (7) – Jul 1, 1998

Loading next page...
 
/lp/elsevier/serotonin-5-ht-2c-receptors-tonically-inhibit-dopamine-da-and-rykV5uKbgd
Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science Inc.
ISSN
0028-3908
eISSN
1873-7064
D.O.I.
10.1016/S0028-3908(98)00078-1
Publisher site
See Article on Publisher Site

Abstract

The novel, preferential 5-HT 2C receptor agonist, Ro 60-0175 (( S )-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine) (2.5 mg/kg, s.c.), markedly suppressed dialysate levels of dopamine (DA) and noradrenaline (NA) levels in the frontal cortex of freely-moving rats without affecting levels of 5-HT. In contrast, the novel and selective 5-HT 2C receptor antagonist, SB-242084 (6-chloro-5-methyl-1-(6-(2-methylpyridin-3-yloxy) pyridin-3-yl carbamoyl) indoline) (10.0 mg/kg, i.p.), markedly increased dialysate levels of DA and NA without modifying those of 5-HT. These data suggest that 5-HT 2C receptors exert a tonic, inhibitory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission.

Journal

NeuropharmacologyElsevier

Published: Jul 1, 1998

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off