Sequence, Genomic Organization, and Chromosomal Localization of the Human LPAP (PTPRCAP) and Mouse CD45-AP/LSM-1 Genes

Sequence, Genomic Organization, and Chromosomal Localization of the Human LPAP (PTPRCAP) and... Human LPAP (lymphocyte phosphatase associated phosphoprotein) and its mouse homologue, CD45-AP (CD45 associated protein) or LSM-1, represent 32- and 30-kDa transmembrane phosphoproteins that noncovalently associate with the tyrosine phosphatase CD45, a key molecule involved in T- and B-lymphocyte activation. Here we report the isolation and sequencing of genomic clones of the human and mouse genes. LPAP (HGMW-approved symbol PTPRCAP) maps to human chromosome 11q13, distal to the BCL-1 breakpoint, and mouse CD45-AP/LSM-1 maps to Chromosome 19B. Both genes span 3 kb and consist of two exons that are separated by a 1.2-kb intron. The promoter regions do not contain TATA boxes, but possess consensus transcriptional initiator sequences that have also been described for other TATA-less genes. The genomic sequences also provide a genetic basis for two different cDNAs (termed CD45-AP and LSM-1, respectively) that have been described in the mouse system. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genomics Elsevier

Sequence, Genomic Organization, and Chromosomal Localization of the Human LPAP (PTPRCAP) and Mouse CD45-AP/LSM-1 Genes

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Publisher
Elsevier
Copyright
Copyright © 1996 Academic Press
ISSN
0888-7543
eISSN
1089-8646
D.O.I.
10.1006/geno.1996.0595
Publisher site
See Article on Publisher Site

Abstract

Human LPAP (lymphocyte phosphatase associated phosphoprotein) and its mouse homologue, CD45-AP (CD45 associated protein) or LSM-1, represent 32- and 30-kDa transmembrane phosphoproteins that noncovalently associate with the tyrosine phosphatase CD45, a key molecule involved in T- and B-lymphocyte activation. Here we report the isolation and sequencing of genomic clones of the human and mouse genes. LPAP (HGMW-approved symbol PTPRCAP) maps to human chromosome 11q13, distal to the BCL-1 breakpoint, and mouse CD45-AP/LSM-1 maps to Chromosome 19B. Both genes span 3 kb and consist of two exons that are separated by a 1.2-kb intron. The promoter regions do not contain TATA boxes, but possess consensus transcriptional initiator sequences that have also been described for other TATA-less genes. The genomic sequences also provide a genetic basis for two different cDNAs (termed CD45-AP and LSM-1, respectively) that have been described in the mouse system.

Journal

GenomicsElsevier

Published: Nov 15, 1996

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