Septal vasopressin modulates anxiety-related behaviour in rats

Septal vasopressin modulates anxiety-related behaviour in rats Arginine vasopressin (AVP) or its V1 receptor antagonist d (CH 2 ) 5 Tyr(Me)AVP was administered directly into the septal brain area of adult male rats by means of inverse microdialysis. Immediately after a 30-min dialysis period, during which either approximately 0.25 ng AVP or 5 ng of the V I antagonist were delivered into the brain tissue, anxiety-related behaviour of the animals was treasured on an elevated plus-maze apparatus. While synthetic AVP failed to alter plus-maze behaviour compared to vehicle-treated controls, animals treated with the V I receptor antagonist made more entries into ( P < 0.01) and spent more time on the open arms ( P < 0.05), indicating reduced anxiety. Since administration of neither AVP nor the V 1 antagonist significantly influenced general locomotor activity of the rats on the plus-maze and in an open field, these data point towards a critical involvement of intraseptally released AVP in the emotional evaluation of novel situations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Septal vasopressin modulates anxiety-related behaviour in rats

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0304-3940
DOI
10.1016/0304-3940(96)13069-X
Publisher site
See Article on Publisher Site

Abstract

Arginine vasopressin (AVP) or its V1 receptor antagonist d (CH 2 ) 5 Tyr(Me)AVP was administered directly into the septal brain area of adult male rats by means of inverse microdialysis. Immediately after a 30-min dialysis period, during which either approximately 0.25 ng AVP or 5 ng of the V I antagonist were delivered into the brain tissue, anxiety-related behaviour of the animals was treasured on an elevated plus-maze apparatus. While synthetic AVP failed to alter plus-maze behaviour compared to vehicle-treated controls, animals treated with the V I receptor antagonist made more entries into ( P < 0.01) and spent more time on the open arms ( P < 0.05), indicating reduced anxiety. Since administration of neither AVP nor the V 1 antagonist significantly influenced general locomotor activity of the rats on the plus-maze and in an open field, these data point towards a critical involvement of intraseptally released AVP in the emotional evaluation of novel situations.

Journal

Neuroscience LettersElsevier

Published: Oct 18, 1996

References

  • Raised corticosterone in the rat after exposure to the elevated plus-maze
    File, S.E.; Zangrossi, H.; Sanders, F.L.; Mabbutt, P.S.
  • The septum and hyper-reactivity: a review
    Fried, P.A.
  • Chronic infusion of a CRH 1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats
    Liebsch, G.; Landgraf, R.; Gerstberger, R.; Probst, J.C.; Wotjak, C.T.; Engelmann, M.; Holsboer, F.; Montkowski, A.

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