Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests

Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and... According to Gray (The neuropsychology of anxiety: an inquiry into the function of the septo-hippocampal system. Oxford: Oxford Univ. Press, 1982; Neural systems, emotion and personality. In: Madden VJ, editor. Neurobiology of learning, emotion, and affect. New York: Raven Press, 1991. p. 273–306.) the septum and hippocampus act in concert to control anxiety. In the present study we examined the roles of these structures in two animal models of anxiety: the elevated plus-maze and the shock-probe burying tests. We found that microinfusions (20 ng/0.4 μl) of the GABA A agonist muscimol into either the lateral or the medial septum increased rats' open-arm exploration in the plus-maze test, and decreased their burying behavior in the shock-probe test. We also found that infusions of the acetylcholinesterase inhibitor physostigmine (10 μg/μl) into the dorsal hippocampus, like intraseptal muscimol (20 ng/0.4 μl), increased open-arm exploration in the plus-maze test, and decreased burying behavior in the shock-probe test. Although combined infusions of intraseptal muscimol and intrahippocampal physostigmine did not increase the magnitude of anxiolysis, this may have been due to “ceiling” effects. Overall, the results confirm that septal GABAergic and hippocampal cholinergic systems are both involved in the modulation of anxiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/S0091-3057(01)00541-X
Publisher site
See Article on Publisher Site

Abstract

According to Gray (The neuropsychology of anxiety: an inquiry into the function of the septo-hippocampal system. Oxford: Oxford Univ. Press, 1982; Neural systems, emotion and personality. In: Madden VJ, editor. Neurobiology of learning, emotion, and affect. New York: Raven Press, 1991. p. 273–306.) the septum and hippocampus act in concert to control anxiety. In the present study we examined the roles of these structures in two animal models of anxiety: the elevated plus-maze and the shock-probe burying tests. We found that microinfusions (20 ng/0.4 μl) of the GABA A agonist muscimol into either the lateral or the medial septum increased rats' open-arm exploration in the plus-maze test, and decreased their burying behavior in the shock-probe test. We also found that infusions of the acetylcholinesterase inhibitor physostigmine (10 μg/μl) into the dorsal hippocampus, like intraseptal muscimol (20 ng/0.4 μl), increased open-arm exploration in the plus-maze test, and decreased burying behavior in the shock-probe test. Although combined infusions of intraseptal muscimol and intrahippocampal physostigmine did not increase the magnitude of anxiolysis, this may have been due to “ceiling” effects. Overall, the results confirm that septal GABAergic and hippocampal cholinergic systems are both involved in the modulation of anxiety.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Jul 8, 2001

References

  • The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines
    Pesold, C; Treit, D
  • Connections of the rat lateral septal complex
    Risold, PY; Swanson, LW
  • Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety
    Rodgers, RJ; Johnson, NJ
  • The effects of intrahippocampal scopolamine infusions on anxiety in rats as measured by the black–white box test
    Smythe, JW; Murphy, D; Bhatnagar, S; Timothy, C; Costall, B
  • The septum and anxiety
    Treit, D; Menard, J

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