Journal of Colloid and Interface Science 517 (2018) 113–123 Contents lists available at ScienceDirect Journal of Colloid and Interface Science journal homepage: www.elsevier.com/locate/jcis Regular Article Self-assembled gelatin-i-carrageenan encapsulation structures for intestinal-targeted release applications Laura G. Gómez-Mascaraque, Beatriz Llavata-Cabrero, Marta Martínez-Sanz, María José Fabra, Amparo López-Rubio Food Safety and Preservation Department, IATA-CSIC, Avda. Agustín Escardino 7, 46980 Paterna, Valencia, Spain graphical a bstract article i nfo abstract Article history: In this work, natural biopolymeric encapsulation structures were developed through the self-assembly of Received 12 December 2017 gelatin and i-carrageenan in aqueous solutions. The interactions of this binary system and of a ternary Revised 29 January 2018 system containing a polyphenol-rich extract were deeply explored for the development of intestinal Accepted 29 January 2018 delivery systems. The processing of the structures (extrusion vs. freeze-drying) greatly inﬂuenced release Available online 1 February 2018 properties, explained by the speciﬁc interactions between gelatin and polyphenols, thus allowing for tun- ing the processing conditions depending on the desired target application. Release was further controlled Keywords: by incorporating a divalent salt, giving raise to extract-loaded i-carrageenan/gelatin capsules with Coacervation adequate release proﬁles for intestinal targeted delivery. These results demonstrate the potential of Polyelectrolyte exploiting biopolymer interactions
Journal of Colloid and Interface Science – Elsevier
Published: May 1, 2018
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