Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects in rats placed on the elevated plus maze

Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects... The objective of this study was to investigate if selective dopamine depletion within the medial prefrontal cortex modifies the anxiety state in rats. Anxiety was evaluated by using the elevated plus maze test, an anxiety model. Dopamine depletion in the medial prefrontal cortex (79% vs. controls) induced a significantly lower preference to stay on open arms together with a reliably lower frequency of open arm entries, as well as a significant increase of percent time spent on closed arms. Although locomotion was also significantly reduced, protected head-dipping and protected stretched attend, novel “ethologically derived” indices of anxiety, were reliably enhanced. Taken together, the results are indicative of enhanced anxiety level despite hypomotility. The findings confirm that prefrontocortical dopamine activation is necessary for coping with an anxiogenic challenge, allowing the animal to display adaptive exploratory responses in a fear-inducing environment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects in rats placed on the elevated plus maze

Brain Research, Volume 762 (1) – Jul 11, 1997

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science B.V.
ISSN
0006-8993
DOI
10.1016/S0006-8993(97)00593-3
Publisher site
See Article on Publisher Site

Abstract

The objective of this study was to investigate if selective dopamine depletion within the medial prefrontal cortex modifies the anxiety state in rats. Anxiety was evaluated by using the elevated plus maze test, an anxiety model. Dopamine depletion in the medial prefrontal cortex (79% vs. controls) induced a significantly lower preference to stay on open arms together with a reliably lower frequency of open arm entries, as well as a significant increase of percent time spent on closed arms. Although locomotion was also significantly reduced, protected head-dipping and protected stretched attend, novel “ethologically derived” indices of anxiety, were reliably enhanced. Taken together, the results are indicative of enhanced anxiety level despite hypomotility. The findings confirm that prefrontocortical dopamine activation is necessary for coping with an anxiogenic challenge, allowing the animal to display adaptive exploratory responses in a fear-inducing environment.

Journal

Brain ResearchElsevier

Published: Jul 11, 1997

References

  • Stretched attended posture, a non-social form of ambivalence, is sensitive to a conflict-reducing drug action
    Kaesermann, H.P.
  • The mesocorticolimbic dopaminergic network: functional and regulatory roles
    Le Moal, M.; Simon, H.
  • The use of a plus-maze to measure anxiety in the mouse
    Lister, R.G.
  • Effects of DN-2327, a new anxiolytic, diazepam and buspirone on exploratory activity of the rat in the elevated plus maze
    Wada, T.; Fukuda, N.

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