Seizure-induced activation of enkephalin- and somatostatin-synthesizing neurons

Seizure-induced activation of enkephalin- and somatostatin-synthesizing neurons The extent of the neuronal network that is activated by kainic acid-induced seizures was anatomically identified and neurochemically characterized. Seizure-activated neurons were identified through the immunocytochemical demonstration of Fos protein in neuronal nuclei. These seizure-activated neurons were characterized by determining if they contained the mRNA for somatostatin or enkephalin, using in situ hybridization procedures. The results demonstrate that a majority of enkephalin- and somatostatin-synthesizing neurons expressed the Fos protein following seizures and that they represent a major component of the kainic acid-induced, seizure-activated neuronal network. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Seizure-induced activation of enkephalin- and somatostatin-synthesizing neurons

Peptides, Volume 16 (5) – Jan 1, 1995

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0196-9781
DOI
10.1016/0196-9781(95)00064-Q
Publisher site
See Article on Publisher Site

Abstract

The extent of the neuronal network that is activated by kainic acid-induced seizures was anatomically identified and neurochemically characterized. Seizure-activated neurons were identified through the immunocytochemical demonstration of Fos protein in neuronal nuclei. These seizure-activated neurons were characterized by determining if they contained the mRNA for somatostatin or enkephalin, using in situ hybridization procedures. The results demonstrate that a majority of enkephalin- and somatostatin-synthesizing neurons expressed the Fos protein following seizures and that they represent a major component of the kainic acid-induced, seizure-activated neuronal network.

Journal

PeptidesElsevier

Published: Jan 1, 1995

References

  • The substantia nigra pars reticulata, seizures and Fos expression
    Applegate, C.D.; Piekut, D.; Pretel, S.
  • Substantia nigra
    Fallon, J.H.; Laughlin, S.E.
  • The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
    Monaghan, D.T.; Bridges, R.J.; Cotman, C.W.
  • Concentrations of mRNAs encoding for preprosomatostatin and preprocholecystokinin are increased after kainic acid-induced seizures
    Olenik, C.; Meyer, D.K.; Marksteiner, J.; Sperk, G.

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