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Drugs R D 2011; 11 (2): 207-213 R&DINSIGHT PROFILE 1179-6901/11/0002-0207 ª 2011 Adis Data Information BV. All rights reserved. Abstract RVX 208 ( RVX - 208 ; RVX000222) is a first-in-class novel small ...
RVX - 208 is a recently reported inhibitor of bromo and extraterminal (BET) family proteins (including BRD2-4 and BRDT) with selectivity for the second bromodomain (BD2), currently in phase III ...
conditions. Some BET inhibitors, such as RVX - 208 , also raise high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 levels. A recent meta-analysis of three small trials (n = 798) found that RVX ...
KIDNEY DISEASE. min/1.73m2. The effect of selective BET inhibition on key renal parameters in this subgroup was assessed. PATHOPHYSIOLOGY, PROGRESSION & Methods: Total of 81 CKD subjects ( RVX - 208 n=58 ...
contributes to cardiovascular disease development but is currently not targeted by therapies. Apabetalone ( RVX - 208 ) – an FDA approved small molecule inhibitor of the epigenetic readers bromodomain and extra ...
for the first time that two BET inhibitors, RVX - 208 , which has entered phase II clinical trials for diverse cardiovascular disorders, and PFI-1, which has been widely studied in oncology, can reactivate HIV-1 ...
PATHOLOGY. EXPERIMENTAL disease and reduction in complement activation is beneficial for kidney function, we have examined the effect of RVX - 208 on complement expression and activity in vitro, AND CLINICAL ...
inhibitors, safer and more selective strategies are needed to advance BET therapeutics as a potential treatment for SUD. Here, we show that RVX - 208 , a clinically tested, BD2-selective BET inhibitor, dose ...
ApoA-I induction represents a potential novel strategy to reduce cardiovascular risk, by generating nascent HDL particles. These studies will provide early evaluation of the effects of RVX - 208 ...
inhibitor RVX - 208 . Anti-IL-1β, anti-IL-6 receptor and anti-TNF-α were also employed to assess the relative contribution of distinct BRD4-related pathways. Vasorelaxation was performed in the presence ...
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