RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia

RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative... •RP5063, an atypical antipsychotic drug (APD), blocked acute phencyclidine (PCP)- as well as amphetamine-induced hyperactivity.•Acute treatment with RP5063 reversed the subchronic (scPCP)-induced novel object recognition (NOR) deficit in mice.•Co-administration of PCP and RP5063 for seven days, bid, delayed the onset of the deficit in NOR deficit for one week.•ScRP5063 administered beginning one week after scPCP withdrawal reversed the NOR deficit for one week.•RP5063 significantly increased cortical dopamine efflux in mice. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Behavioural Brain Research Elsevier

RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
0166-4328
D.O.I.
10.1016/j.bbr.2017.02.036
Publisher site
See Article on Publisher Site

Abstract

•RP5063, an atypical antipsychotic drug (APD), blocked acute phencyclidine (PCP)- as well as amphetamine-induced hyperactivity.•Acute treatment with RP5063 reversed the subchronic (scPCP)-induced novel object recognition (NOR) deficit in mice.•Co-administration of PCP and RP5063 for seven days, bid, delayed the onset of the deficit in NOR deficit for one week.•ScRP5063 administered beginning one week after scPCP withdrawal reversed the NOR deficit for one week.•RP5063 significantly increased cortical dopamine efflux in mice.

Journal

Behavioural Brain ResearchElsevier

Published: Aug 14, 2017

References

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