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. Simultaneous treatment with both regeneration factors enhanced the cytoprotective effect. The PI 3 ‐K/ Akt kinase inhibitor, wortmannin, and the STAT3 pathway inhibitor, Tyrphostin AG490, both effectively ...
, the mammalian target of rapamycin (mTOR) and the STAT3 survival pathways is usually observed in many cancer cell types [ 3 ]. Several studies suggested that the Akt , mTOR and STAT3 cascades contributed to cell ...
of ERK1/2, Stat3 and NF-κB in Cyclin D1 expression induced by nicotine. Although numerous reports suggest that nicotine promotes tumorigenesis through phosphatidylinositol- 3 - kinase (PI3K)/ AKT , Raf/mitogen ...
-ERK pathway by Akt , Science , 1999 , 286 ,( 5445 ) 1738 – 1741 . Google Scholar Crossref Search ADS PubMed WorldCat E. Castellano and J. Downward, Role of RAS in the regulation of PI 3 - kinase , Curr ...
transducer and activator of transcription 3 ( STAT3 ) activation, and the protein was stabilized by AKT - mediated glycogen synthase kinase 3 beta (GSK3β) inactivation. Genetic (siRNA) or pharmacological ...
on the engagement of the insulin receptor substrate (IRS)-1/ PI 3 - kinase pathway [35]. In the present work, we sought to study further the role of leptin-activating T cells and the trophic effect of leptin preventing ...
patients with high expression of CMTM4 had markedly favorable overall survival (Fig. 1I). These results suggested that CMTM4 probably plays an important role in CRC. Figure 3 Open in new tabDownload slide ...
to the inhibition of the PI3K/ AKT signaling pathway and the role of anthrax toxins in this process. AKT (protein kinase B) is an established pluripotent key mediator of cell survival after various insults, including ...
- Akt (4060S), mTOR (2983T)/p-mTOR (5536T), Janus-activated kinase (Jak) 2 (3230T)/p-Jak2 (4406T), signal transducers and activators of transcription 3 ( Stat3 ) (9139T)/p- Stat3 (9145T), PTEN (9188S)/p-PTEN ...
actions by activating multiple signaling pathways and mediators including PI3K/a serine/threonine kinase also known as protein kinase B ( Akt ), endothelial nitric oxide synthase (eNOS), extracellular signal ...
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