Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex

Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral... The results of the present study clearly shows that a correlation exists between nitric oxide (NO) and γ-aminobutyric acid transaminase (GABAT-T) activity as well as γ-aminobutyric acid (GABA), glutamic acid and the activity of glutamic acid decarboxylase (GAD). Supporting of this 10 min after the administration of l -Arginine ( l -Arg) increased GABA concentration and diminished the activity of GABA-T. There was no change in GAD activity and glutamic acid level. Administration of convulsion inducing agent Picrotoxin (PCT) decreased the NO concentration in the brain and enhanced the activity of GABA-T, and the fact that the NOS inhibitor ( N G -nitro- l -Arg methyl ester ( l -NAME) diminished the activity of NOS and increased the activity of GABA-T provide another support for the involvement of NO on GABA-T activity. The present study clearly showed that high concentrations of NO in the brain suppresses the activity of GABA-T. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Ltd
ISSN
0006-8993
DOI
10.1016/S0006-8993(99)01692-3
Publisher site
See Article on Publisher Site

Abstract

The results of the present study clearly shows that a correlation exists between nitric oxide (NO) and γ-aminobutyric acid transaminase (GABAT-T) activity as well as γ-aminobutyric acid (GABA), glutamic acid and the activity of glutamic acid decarboxylase (GAD). Supporting of this 10 min after the administration of l -Arginine ( l -Arg) increased GABA concentration and diminished the activity of GABA-T. There was no change in GAD activity and glutamic acid level. Administration of convulsion inducing agent Picrotoxin (PCT) decreased the NO concentration in the brain and enhanced the activity of GABA-T, and the fact that the NOS inhibitor ( N G -nitro- l -Arg methyl ester ( l -NAME) diminished the activity of NOS and increased the activity of GABA-T provide another support for the involvement of NO on GABA-T activity. The present study clearly showed that high concentrations of NO in the brain suppresses the activity of GABA-T.

Journal

Brain ResearchElsevier

Published: Aug 7, 1999

References

  • MAO, COMT and GABA-T activities in primary astroglial cultures
    Hansson, E.; Sellstronm, A.
  • Some effects of monoamine oxidase inhibitors on the metabolism of aminobutyric acid in rat brain
    Popov, N.; Matthies, H.
  • Effect of inhibiting NO synthesis on hippocampal extracellular glutamate concentration in seizure induced by kainic acid
    Sophie, A.; Monnet, R.; Heron, A.; Seyletcz, J.; Pinard, K.
  • Gamma aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues
    Tillakaratne, N.J.; Medina-Kauwe, L.; Gibson, K.M.
  • Distribution of GABA and GABA receptors in mammalian brain: potential targets for drug development
    Young, A.B.; Chu, D.
  • Quantitative methods for measuring the histochemical distribution of alanine glutamate and glutamine in brain
    Young, R.L.; Lowry, O.H.

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