Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey

Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey IntroductionMutations in the LRRK2 and alpha-synuclein (SNCA) genes are well-established causes of autosomal dominant Parkinson's disease (PD). However, their frequency differs widely between ethnic groups. Only three studies have screened all coding regions of LRRK2 and SNCA in European samples so far. In Turkey, the role of LRRK2 in Parkinson's disease has been studied fragmentarily, and the incidence of SNCA copy number variations is unknown. The purpose of this study is to determine the frequency of LRRK2 and SNCA mutations in autosomal dominant PD in Turkey. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Parkinsonism & Related Disorders Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
1353-8020
D.O.I.
10.1016/j.parkreldis.2017.12.007
Publisher site
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Abstract

IntroductionMutations in the LRRK2 and alpha-synuclein (SNCA) genes are well-established causes of autosomal dominant Parkinson's disease (PD). However, their frequency differs widely between ethnic groups. Only three studies have screened all coding regions of LRRK2 and SNCA in European samples so far. In Turkey, the role of LRRK2 in Parkinson's disease has been studied fragmentarily, and the incidence of SNCA copy number variations is unknown. The purpose of this study is to determine the frequency of LRRK2 and SNCA mutations in autosomal dominant PD in Turkey.

Journal

Parkinsonism & Related DisordersElsevier

Published: Mar 1, 2018

References

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