Introduction</h5> Fas (CD95; tumor necrosis factor receptor superfamily member 6, TNFRSF6) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. Crosslinking of Fas with its natural ligand – FasL (CD95L, CD178) or with agonistic antibodies induces apoptosis in sensitive cells. Fas-induced apoptosis is involved in the cytotoxic activity of T cells and NK cells ( Davidson et al. 2002 ), peripheral B cell tolerance and elimination of self-reactive T cells ( Ju et al. 1995; Stranges et al. 2007 ). Fas can also induce non-apoptotic signaling resulting in cell proliferation, angiogenesis, fibrosis and inflammation ( Mocellin 2010; Ramaswamy et al. 2009 ).</P>Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus that gives rise to genital herpes. Epithelial cells and keratinocytes are the primary target cells for HSV-2, but it also infects peripheral neuronal and immune cells ( Gupta et al. 2007; Whitley 2001 ). In the majority of infected individuals, the virus establishes latency in sacral ganglia, where it can be reactivated causing recurrent genital disease ( Gupta et al. 2007; Whitley 2001 ). Multiple cell types have been shown to contribute to the innate and adaptive
Immunobiology – Elsevier
Published: Dec 1, 2014
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