Introduction</h5> Fas (CD95; tumor necrosis factor receptor superfamily member 6, TNFRSF6) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. Crosslinking of Fas with its natural ligand – FasL (CD95L, CD178) or with agonistic antibodies induces apoptosis in sensitive cells. Fas-induced apoptosis is involved in the cytotoxic activity of T cells and NK cells ( Davidson et al. 2002 ), peripheral B cell tolerance and elimination of self-reactive T cells ( Ju et al. 1995; Stranges et al. 2007 ). Fas can also induce non-apoptotic signaling resulting in cell proliferation, angiogenesis, fibrosis and inflammation ( Mocellin 2010; Ramaswamy et al. 2009 ).</P>Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus that gives rise to genital herpes. Epithelial cells and keratinocytes are the primary target cells for HSV-2, but it also infects peripheral neuronal and immune cells ( Gupta et al. 2007; Whitley 2001 ). In the majority of infected individuals, the virus establishes latency in sacral ganglia, where it can be reactivated causing recurrent genital disease ( Gupta et al. 2007; Whitley 2001 ). Multiple cell types have been shown to contribute to the innate and adaptive
Immunobiology – Elsevier
Published: Dec 1, 2014
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera