Rodent malaria models: insights into human disease and parasite biology

Rodent malaria models: insights into human disease and parasite biology Available online at www.sciencedirect.com ScienceDirect Rodent malaria models: insights into human disease and parasite biology 1,2 2 Mariana De Niz and Volker T Heussler The use of rodents as model organisms to study human (reviewed in Ref. [2]). These genetic similarities, disease is based on the genetic and physiological similarities together with the availability of a plethora of inbred between the species. Successful molecular methods to and outbred mouse strains with varied immunological generate transgenic reporter or humanized rodents has makeup and powerful genetic methods for generating rendered rodents as powerful tools for understanding transgenic mice such as CRISPR/Cas9, make rodents an biological processes and host-pathogen interactions relevant invaluable tool for research. Moreover, the increased use to humans. In malaria research, rodent models have been of humanized mouse models and xenografted mice, has pivotal for the study of liver stages, syndromes arising from further led to successful in vivo investigations of human blood stages of infection, and malaria transmission to and from malaria pathology, host-pathogen dynamics, and anti- the mammalian host. Importantly, many in vivo findings are malarial drug efficacy. The main characteristics of the comparable to pathology observed in humans only when five most studied rodent strains is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Microbiology Elsevier

Rodent malaria models: insights into human disease and parasite biology

Loading next page...
 
/lp/elsevier/rodent-malaria-models-insights-into-human-disease-and-parasite-biology-3I6yOPShoN
Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
1369-5274
D.O.I.
10.1016/j.mib.2018.09.003
Publisher site
See Article on Publisher Site

Abstract

Available online at www.sciencedirect.com ScienceDirect Rodent malaria models: insights into human disease and parasite biology 1,2 2 Mariana De Niz and Volker T Heussler The use of rodents as model organisms to study human (reviewed in Ref. [2]). These genetic similarities, disease is based on the genetic and physiological similarities together with the availability of a plethora of inbred between the species. Successful molecular methods to and outbred mouse strains with varied immunological generate transgenic reporter or humanized rodents has makeup and powerful genetic methods for generating rendered rodents as powerful tools for understanding transgenic mice such as CRISPR/Cas9, make rodents an biological processes and host-pathogen interactions relevant invaluable tool for research. Moreover, the increased use to humans. In malaria research, rodent models have been of humanized mouse models and xenografted mice, has pivotal for the study of liver stages, syndromes arising from further led to successful in vivo investigations of human blood stages of infection, and malaria transmission to and from malaria pathology, host-pathogen dynamics, and anti- the mammalian host. Importantly, many in vivo findings are malarial drug efficacy. The main characteristics of the comparable to pathology observed in humans only when five most studied rodent strains is

Journal

Current Opinion in MicrobiologyElsevier

Published: Dec 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off