Available online at www.sciencedirect.com ScienceDirect Rodent malaria models: insights into human disease and parasite biology 1,2 2 Mariana De Niz and Volker T Heussler The use of rodents as model organisms to study human (reviewed in Ref. ). These genetic similarities, disease is based on the genetic and physiological similarities together with the availability of a plethora of inbred between the species. Successful molecular methods to and outbred mouse strains with varied immunological generate transgenic reporter or humanized rodents has makeup and powerful genetic methods for generating rendered rodents as powerful tools for understanding transgenic mice such as CRISPR/Cas9, make rodents an biological processes and host-pathogen interactions relevant invaluable tool for research. Moreover, the increased use to humans. In malaria research, rodent models have been of humanized mouse models and xenografted mice, has pivotal for the study of liver stages, syndromes arising from further led to successful in vivo investigations of human blood stages of infection, and malaria transmission to and from malaria pathology, host-pathogen dynamics, and anti- the mammalian host. Importantly, many in vivo ﬁndings are malarial drug efﬁcacy. The main characteristics of the comparable to pathology observed in humans only when ﬁve most studied rodent strains is
Current Opinion in Microbiology – Elsevier
Published: Dec 1, 2018
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