Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study

Risk of death from cardiovascular disease associated with low-level arsenic exposure among... High levels of arsenic exposure have been associated with increases in cardiovascular disease risk. However, studies of arsenic's effects at lower exposure levels are limited and few prospective studies exist in the United States using long-term arsenic exposure biomarkers. We conducted a prospective analysis of the association between toenail arsenic and cardiovascular disease mortality using longitudinal data collected on 3939 participants in the New Hampshire Skin Cancer Study. Using Cox proportional hazard models adjusted for potential confounders, we estimated hazard ratios and 95% confidence intervals associated with the risk of death from any cardiovascular disease, ischemic heart disease, and stroke, in relation to natural-log transformed toenail arsenic concentrations. In this US population, although we observed no overall association, arsenic exposure measured from toenail clipping samples was related to an increased risk of ischemic heart disease mortality among long-term smokers (as reported at baseline), with increased hazard ratios among individuals with ≥31 total smoking years (HR: 1.52, 95% CI: 1.02, 2.27), ≥ 30 pack-years (HR: 1.66, 95% CI: 1.12, 2.45), and among current smokers (HR: 1.69, 95% CI: 1.04, 2.75). These results are consistent with evidence from more highly exposed populations suggesting a synergistic relationship between arsenic exposure and smoking on health outcomes and support a role for lower-level arsenic exposure in ischemic heart disease mortality. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Toxicology and Applied Pharmacology Elsevier

Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study

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Publisher
Elsevier
Copyright
Copyright © 2015 Elsevier Ltd
ISSN
0041-008x
D.O.I.
10.1016/j.taap.2015.05.013
Publisher site
See Article on Publisher Site

Abstract

High levels of arsenic exposure have been associated with increases in cardiovascular disease risk. However, studies of arsenic's effects at lower exposure levels are limited and few prospective studies exist in the United States using long-term arsenic exposure biomarkers. We conducted a prospective analysis of the association between toenail arsenic and cardiovascular disease mortality using longitudinal data collected on 3939 participants in the New Hampshire Skin Cancer Study. Using Cox proportional hazard models adjusted for potential confounders, we estimated hazard ratios and 95% confidence intervals associated with the risk of death from any cardiovascular disease, ischemic heart disease, and stroke, in relation to natural-log transformed toenail arsenic concentrations. In this US population, although we observed no overall association, arsenic exposure measured from toenail clipping samples was related to an increased risk of ischemic heart disease mortality among long-term smokers (as reported at baseline), with increased hazard ratios among individuals with ≥31 total smoking years (HR: 1.52, 95% CI: 1.02, 2.27), ≥ 30 pack-years (HR: 1.66, 95% CI: 1.12, 2.45), and among current smokers (HR: 1.69, 95% CI: 1.04, 2.75). These results are consistent with evidence from more highly exposed populations suggesting a synergistic relationship between arsenic exposure and smoking on health outcomes and support a role for lower-level arsenic exposure in ischemic heart disease mortality.

Journal

Toxicology and Applied PharmacologyElsevier

Published: Sep 1, 2015

References

  • Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern Taiwan
    Chen, C.L.; Chiou, H.Y.; Hsu, L.I.; Hsueh, Y.M.; Wu, M.M.
  • Arsenic-induced oxidative stress and its reversibility
    Flora, S.J.S.
  • Low-level arsenic exposure, AS3MT gene polymorphism and cardiovascular diseases in rural Texas counties
    Gong, G.; O'Bryant, S.E.
  • A case-cohort study examining lifetime exposure to inorganic arsenic in drinking water and diabetes mellitus
    James, K.A.; Marshall, J.A.; Hokanson, J.E.; Meliker, J.R.; Zerbe, G.O.
  • Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire
    Karagas, M.R.; Tosteson, T.D.; Morris, J.S.; Demidenko, E.; Mott, L.A.
  • Arsenic in public water supplies and cardiovascular mortality in Spain
    Medrano, M.A.; Boix, R.; Pastor-Barriuso, R.; Palau, M.; Damian, J.
  • Survival after squamous cell and basal cell carcinoma of the skin: a retrospective cohort analysis
    Rees, J.R.; Zens, M.S.; Celaya, M.O.; Riddle, B.L.; Karagas, M.R.
  • Increased risk of QT prolongation associated with atherosclerotic diseases in arseniasis-endemic area in southwestern coast of Taiwan
    Wang, C.H.; Chen, C.L.; Hsiao, C.K.; Chiang, F.T.; Hsu, L.I.
  • Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh
    Wu, F.; Jasmine, F.; Kibriya, M.G.; Liu, M.; Cheng, X.

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