1 Introduction</h5> Psoriasis is one of the most common chronic autoinflammatory skin diseases. It is characterized by the proliferation of basal layer of epidermis to compensate for skin loss, abnormal keratinocyte differentiation, and massive infiltration of leukocytes. Approximately 2% of the world population is affected ( Berneburg et al., 2013 ). Although, pathogenesis of psoriasis is still not completely understood, there is ample evidence to indicate that genetic inheritance of certain, immune cells in the skin can lead to psoriasis ( Jullien, 2012 ). In addition, environmental factors such as trauma, stress, infections, and drugs may trigger psoriasis ( Monteleone et al., 2011 ). Common psoriasis symptoms include red, scaly, and raised patches on the skin. The condition affects patients’ life, both physically and mentally ( Grozdev et al., 2012 ). Although no treatment measures are available to completely cure psoriasis, a few treatment modalities can be used for relieving psoriatic lesions. Topical treatments such as vitamin D analogs and topical corticosteroids are utilized for mild conditions ( Carrascosa et al., 2009 ). Light therapy or systemic medications such as psoralen plus ultraviolet A therapy, ultraviolet B phototherapy, methotrexate, and cyclosporin are commonly applied for more severe cases
European Journal of Pharmacology – Elsevier
Published: Feb 5, 2016
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