Rhodomyrtone as a potential anti-proliferative and apoptosis inducing agent in HaCaT keratinocyte cells

Rhodomyrtone as a potential anti-proliferative and apoptosis inducing agent in HaCaT keratinocyte... 1 Introduction</h5> Psoriasis is one of the most common chronic autoinflammatory skin diseases. It is characterized by the proliferation of basal layer of epidermis to compensate for skin loss, abnormal keratinocyte differentiation, and massive infiltration of leukocytes. Approximately 2% of the world population is affected ( Berneburg et al., 2013 ). Although, pathogenesis of psoriasis is still not completely understood, there is ample evidence to indicate that genetic inheritance of certain, immune cells in the skin can lead to psoriasis ( Jullien, 2012 ). In addition, environmental factors such as trauma, stress, infections, and drugs may trigger psoriasis ( Monteleone et al., 2011 ). Common psoriasis symptoms include red, scaly, and raised patches on the skin. The condition affects patients’ life, both physically and mentally ( Grozdev et al., 2012 ). Although no treatment measures are available to completely cure psoriasis, a few treatment modalities can be used for relieving psoriatic lesions. Topical treatments such as vitamin D analogs and topical corticosteroids are utilized for mild conditions ( Carrascosa et al., 2009 ). Light therapy or systemic medications such as psoralen plus ultraviolet A therapy, ultraviolet B phototherapy, methotrexate, and cyclosporin are commonly applied for more severe cases http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2015 Elsevier B.V.
ISSN
0014-2999
DOI
10.1016/j.ejphar.2015.12.005
pmid
26687635
Publisher site
See Article on Publisher Site

Abstract

1 Introduction</h5> Psoriasis is one of the most common chronic autoinflammatory skin diseases. It is characterized by the proliferation of basal layer of epidermis to compensate for skin loss, abnormal keratinocyte differentiation, and massive infiltration of leukocytes. Approximately 2% of the world population is affected ( Berneburg et al., 2013 ). Although, pathogenesis of psoriasis is still not completely understood, there is ample evidence to indicate that genetic inheritance of certain, immune cells in the skin can lead to psoriasis ( Jullien, 2012 ). In addition, environmental factors such as trauma, stress, infections, and drugs may trigger psoriasis ( Monteleone et al., 2011 ). Common psoriasis symptoms include red, scaly, and raised patches on the skin. The condition affects patients’ life, both physically and mentally ( Grozdev et al., 2012 ). Although no treatment measures are available to completely cure psoriasis, a few treatment modalities can be used for relieving psoriatic lesions. Topical treatments such as vitamin D analogs and topical corticosteroids are utilized for mild conditions ( Carrascosa et al., 2009 ). Light therapy or systemic medications such as psoralen plus ultraviolet A therapy, ultraviolet B phototherapy, methotrexate, and cyclosporin are commonly applied for more severe cases

Journal

European Journal of PharmacologyElsevier

Published: Feb 5, 2016

References

  • Comparative study of the effect of narrowband ultraviolet B phototherapy plus methotrexate vs. narrowband ultraviolet B alone and methotrexate alone in the treatment of plaque‐type psoriasis
    Al‐Hamamy, H.R.; Al‐Mashhadani, S.A.; Mustafa, I.N.
  • New acylphloroglucinols from the leaves of Rhodomyrtus tomentosa
    Hiranrat, A.; Mahabusarakam, W.
  • Chinese herbal medicine (Tuhuai extract) exhibits topical anti‐proliferative and anti‐inflammatory activity in murine disease models
    Man, M.Q.; Shi, Y.; Man, M.; Lee, S.H.; Demerjian, M.; Chang, S.; Feingold, K.R.; Elias, P.M.
  • Psoriasis: from pathogenesis to novel therapeutic approaches
    Monteleone, G.; Pallone, F.; MacDonald, T.; Chimenti, S.; Costanzo, A.
  • Rottlerin: a multifaced regulator of keratinocyte cell cycle
    Valacchi, G.; Pecorelli, A.; Mencarelli, M.; Carbotti, P.; Fortino, V.; Muscettola, M.; Maioli, E.

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