Article history: Co-encapsulated doxorubicin (DOX) and curcumin (CUR) in poly(butyl cyanoacrylate) nanoparti- Received 4 November 2011 cles (PBCA-NPs) were prepared with emulsion polymerization and interfacial polymerization. The Received in revised form mean particle size and mean zeta potential of CUR–DOX–PBCA-NPs were 133 ± 5.34 nm in diam- 27 December 2011 eter and +32.23 ± 4.56 mV, respectively. The entrapment efﬁciencies of doxorubicin and curcumin Accepted 9 January 2012 were 49.98 ± 3.32% and 94.52 ± 3.14%, respectively. Anticancer activities and reversal efﬁcacy of the Available online 17 January 2012 formulations and various combination approaches were assessed using 3-[4,5-dimethylthiazol-2-yl] 2,5- diphenyltetrazolium bromide assay and western blotting. The results showed that the dual-agent loaded Keywords: PBCA-NPs system had the similar cytotoxicity to co-administration of two single-agent loaded PBCA-NPs Curcumin (DOX–PBCA-NPs + CUR–PBCA-NPs), which was slightly higher than that of the free drug combination Doxorubicin (DOX + CUR) and one free drug/another agent loaded PBCA-NPs combination (DOX + CUR–PBCA-NPs or Poly(butyl cyanoacrylate) nanoparticles Multidrug resistance CUR + DOX–PBCA-NPs). The simultaneous administration of doxorubicin and curcumin achieved the highest reversal efﬁcacy and down-regulation of P-glycoprotein in MCF-7/ADR cell lines, an MCF-7 breast carcer cell line resistant to adriamycin. Multidrug resistance can be enhanced
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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