Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy

Renal connective tissue growth factor correlates with glomerular basement membrane thickness and... Diabetic renal disease is characterized by accumulation of extracellular matrix, glomerulosclerosis, and tubulointerstitial fibrosis. Connective tissue growth factor (CTGF) is implicated in these changes, as it contributes to new matrix synthesis and is increased in the diabetic kidney. CTGF also inhibits mesangial matrix degradation through up-regulation of the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1). In a non-human primate model of diabetes, we determined whether the level of renal CTGF protein before development of albuminuria correlated with renal matrix and TIMP-1 changes and whether renal CTGF predicts progression to albuminuria. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Diabetes and its Complications Elsevier

Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy

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Publisher
Elsevier
Copyright
Copyright © 2008 Elsevier Ltd
ISSN
1056-8727
DOI
10.1016/j.jdiacomp.2007.07.001
Publisher site
See Article on Publisher Site

Abstract

Diabetic renal disease is characterized by accumulation of extracellular matrix, glomerulosclerosis, and tubulointerstitial fibrosis. Connective tissue growth factor (CTGF) is implicated in these changes, as it contributes to new matrix synthesis and is increased in the diabetic kidney. CTGF also inhibits mesangial matrix degradation through up-regulation of the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1). In a non-human primate model of diabetes, we determined whether the level of renal CTGF protein before development of albuminuria correlated with renal matrix and TIMP-1 changes and whether renal CTGF predicts progression to albuminuria.

Journal

Journal of Diabetes and its ComplicationsElsevier

Published: Jul 1, 2008

References

  • The effects of aminoguanidine on renal changes in a baboon model of Type 1 diabetes
    Birrell, A.M.; Heffernan, S.J.; Kirwan, P.; McLennan, S.; Gillin, A.G.; Yue, D.K.
  • Pathophysiology of diabetic nephropathy
    Cooper, M.E.; Gilbert, R.E.; Epstein, M.
  • A baboon ( Papio hamadryas ) model of insulin-dependent diabetes
    Heffernan, S.; Phippard, A.; Sinclair, A.; McLennan, S.; Hennessy, A.; Gillin, A.; Horvath, J.; Tiller, D.; Yue, D.; Turtle, J.
  • Molecular mechanism of diabetic nephropathy
    Lehmann, R.; Schleicher, E.D.
  • Decreased matrix degradation in diabetic nephropathy: Effects of ACE inhibition on the expression and activities of matrix metalloproteinases
    McLennan, S.V.; Kelly, D.J.; Cox, A.J.; Cao, Z.; Lyons, J.G.; Yue, D.K.; Gilbert, R.E.
  • The time has come to target connective tissue growth factor in diabetic complications
    Twigg, S.M.; Cooper, M.E.
  • Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis
    Yokoi, H.; Mukoyama, M.; Sugawara, A.; Mori, K.; Nagae, T.; Makino, H.; Suganami, T.; Yahata, K.; Fujinaga, Y.; Tanaka, I.; Nakao, K.

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