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that the sustained release of rhBMP- 2 from NP effectively contributed to the differentiation of osteoblasts. In a rat spinal fusion model, the volume and quality of newly formed bone was higher in the NP group than ...
Pitfalls in the use of bone morphogenetic protein 2 for bone ailments Area of treatment with recombinant human BMP- 2 . Number of patients . Human /animal study . Complication statistics . Outcome . Nonspinal ...
the effect with that of recombinant human bone morphogenetic protein - 2 (rhBMP- 2 ) in a critical-sized cranial defect model. Forty New Zealand white rabbits were randomly divided into 4 groups. Defect sizing 15 ...
(n = 3–4). Abbreviations: BMP- 2 , bone morphogenetic protein 2 ; GAG, glycosaminoglycan; MSC, mesenchymal stem cell; rhBMP- 2 , recombinant human BMP- 2 . Quantification of BMP- 2 Release BMP- 2 MSC in GAG ...
control the release of incorporated BMP2. Figure 2 Open in new tabDownload slide Loading efficacy and release profile of bone morphogenetic protein - 2 (BMP2) from the coacervate. (A): BMP2 coacervate ...
for the tumour necrosis factor (TNF)-α receptor 1 knock-out (TNFR1–/–) 6, 9 and 12 days post-implantation of 1 µg of recombinant human bone morphogenetic protein - 2 . Weight of individual tissues was calculated from ...
into hydroxyapatite or morphogenetic protein on the bone repair process in the distal metaphysis of rat femur. Material and methods Materials Elastin matrix derived from bovine auricular cartilage. The elastin matrices ...
), to promote MSC differentiation. Among all BMPs analyzed, recombinant human BMP- 2 and BMP-7 (rhBMP- 2 and rhBMP-7) have shown overall positive results on promoting bone regeneration [ 2 ]. However, BMPs ...
microparticles in PBS (white). Abbreviation: BMP, bone morphogenetic protein ; TGF, transforming growth factor. Figure 1 Open in new tabDownload slide Cumulative release of TGF-β1 from gelatin microparticles ...
, Morris EA. The effect of recombinant human bone morphogenetic protein ‐ 2 (rhBMP‐ 2 ) on the healing of full‐thickness defects of articular cartilage . J Bone Joint Surg Am 1997 ; 79 : 1452 – 1463 . Google ...
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