Relationships between chromatin organization and DNA methylation in determining gene expression

Relationships between chromatin organization and DNA methylation in determining gene expression Chromatin is the natural substrate for the control of gene expression. Chromatin contains DNA, the transcriptional machinery and structural proteins such as histones. Recent advances demonstrate that transcriptional activity of a gene is largely controlled by the packaging of the template within chromatin. The covalent modification of chromatin provides an attractive mechanism for establishing and maintaining stable states of gene activity. DNA methylation and histone acetylation alter the nucleosomal infrastructure to repress or activate transcription. These covalent modifications have causal roles in both promoter-specific events and the global control of chromosomal activity. DNA methylation and histone acetylation have a major impact in both oncogenic transformation and normal development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Seminars in Cancer Biology Elsevier

Relationships between chromatin organization and DNA methylation in determining gene expression

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Publisher
Elsevier
Copyright
Copyright © 1999 Academic Press
ISSN
1044-579X
eISSN
1096-3650
DOI
10.1006/scbi.1999.0134
Publisher site
See Article on Publisher Site

Abstract

Chromatin is the natural substrate for the control of gene expression. Chromatin contains DNA, the transcriptional machinery and structural proteins such as histones. Recent advances demonstrate that transcriptional activity of a gene is largely controlled by the packaging of the template within chromatin. The covalent modification of chromatin provides an attractive mechanism for establishing and maintaining stable states of gene activity. DNA methylation and histone acetylation alter the nucleosomal infrastructure to repress or activate transcription. These covalent modifications have causal roles in both promoter-specific events and the global control of chromosomal activity. DNA methylation and histone acetylation have a major impact in both oncogenic transformation and normal development.

Journal

Seminars in Cancer BiologyElsevier

Published: Oct 1, 1999

References

  • Multiple roles for DNA methylation in gametic imprinting
    22.*wa@xNeumann, B; Barlow, DP
  • DNA methylation directs a time-dependent repression of transcription initiation
    42.*wa@xKass, SU; Landsberger, N; Wolffe, AP
  • Remodeling of regulatory nucleoprotein complexes during meiotic maturation of the Xenopus oocyte
    70b.@xLandsberger, N; Wolffe, AP
  • An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA
    79.*wa@xMatsuo, K; Silke, J; Georgiev, O; Marti, P; Giovannini, N; Rungger, D

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