Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus

Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and... Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP(a)) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is associated with inflammatory markers, fibrinolytic factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425 men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening program were studied. CRF was measured using peak oxygen uptake with expired gas analysis during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein (CRP; r = −0.27, p <0.05), white blood cell count (r = −0.13, p <0.05), fibrinogen (r = −0.28, p <0.05), LP(a) (r = −0.53, p <0.05), tissue plasminogen activator (t-PA) antigen (r = −0.65, p <0.05), and plasminogen activator inhibitor-1 activity (r = −0.17, p <0.05). Men in the highest tertile of CRF had significantly lower CRP, white blood cell count, fibrinogen, LP(a), and t-PA than men in the lowest tertile of CRF (all p <0.05). In separate multivariable linear regression models that adjusted for age, body mass index, smoking, lipid profiles, glucose, and systolic blood pressure, CRP (β = −0.23, p <0.05), white blood cell count (β = −0.16, p <0.05), fibrinogen (β = −0.24, p <0.05), LP(a) (β = −0.28, p <0.05), and t-PA (β = −0.69, p <0.05) were each inversely associated with CRF. Each MET increment higher peak oxygen uptake was associated with a lower odds ratio of having abnormal LP(a) (odds ratio 0.43, 95% confidence interval 0.20 to 0.91) in a multivariate logistic regression model. In conclusion, CRF was inversely associated with inflammatory markers, fibrinolytic factors, and LP(a) in men with type 2 diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Cardiology Elsevier

Relation of Cardiorespiratory Fitness to Inflammatory Markers, Fibrinolytic Factors, and Lipoprotein(a) in Patients With Type 2 Diabetes Mellitus

Loading next page...
 
/lp/elsevier/relation-of-cardiorespiratory-fitness-to-inflammatory-markers-1D0bza0GsR
Publisher
Elsevier
Copyright
Copyright © 2008 Elsevier Inc.
ISSN
0002-9149
D.O.I.
10.1016/j.amjcard.2008.05.012
Publisher site
See Article on Publisher Site

Abstract

Increased inflammation, fibrinolytic factors, and lipoprotein(a) (LP(a)) were associated with increased cardiovascular events in patients with type 2 diabetes, whereas higher levels of cardiorespiratory fitness (CRF) were associated with a lower incidence of cardiovascular mortality. Whether CRF is associated with inflammatory markers, fibrinolytic factors, and LP(a) in patients with type 2 diabetes was investigated. A total of 425 men with type 2 diabetes (mean age 55 ± 8 years) who participated in a medical screening program were studied. CRF was measured using peak oxygen uptake with expired gas analysis during a symptom-limited exercise test. CRF inversely correlated with C-reactive protein (CRP; r = −0.27, p <0.05), white blood cell count (r = −0.13, p <0.05), fibrinogen (r = −0.28, p <0.05), LP(a) (r = −0.53, p <0.05), tissue plasminogen activator (t-PA) antigen (r = −0.65, p <0.05), and plasminogen activator inhibitor-1 activity (r = −0.17, p <0.05). Men in the highest tertile of CRF had significantly lower CRP, white blood cell count, fibrinogen, LP(a), and t-PA than men in the lowest tertile of CRF (all p <0.05). In separate multivariable linear regression models that adjusted for age, body mass index, smoking, lipid profiles, glucose, and systolic blood pressure, CRP (β = −0.23, p <0.05), white blood cell count (β = −0.16, p <0.05), fibrinogen (β = −0.24, p <0.05), LP(a) (β = −0.28, p <0.05), and t-PA (β = −0.69, p <0.05) were each inversely associated with CRF. Each MET increment higher peak oxygen uptake was associated with a lower odds ratio of having abnormal LP(a) (odds ratio 0.43, 95% confidence interval 0.20 to 0.91) in a multivariate logistic regression model. In conclusion, CRF was inversely associated with inflammatory markers, fibrinolytic factors, and LP(a) in men with type 2 diabetes.

Journal

The American Journal of CardiologyElsevier

Published: Sep 15, 2008

References

  • Biological surrogates for enhancing cardiovascular risk prediction in type 2 diabetes mellitus
    Clair, L.S.; Ballantyne, C.M.
  • Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease
    Bassuk, S.S.; Manson, J.E.
  • Effects of maximal exercise and venous occlusion on fibrinolytic activity in physically active and inactive men
    Szymanski, L.M.; Pate, R.R.; Durstine, J.L.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off