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regulatory network has not been specifically targeted in virulence studies. The studies discussed in this review, however, point to a clear need for more detailed experiments, with a systematic approach across ...
of oxidative stress, including metal homeostasis, metabolism and virulence [55, 107, 108]. In Bacillus subtilis, inactivation of perR leads to increased expression of fur and iron starvation [82]. To examine ...
, pathogenic gram-positive bacteria express virulence factors in a codY-dependant manner. This is true for the anthrax toxins of Bacillus anthracis and the haemolysins of Staphylococcus aureus. The purpose ...
multicellular development, or biofilm formation [11, 19, 20]. As a model system for biofilm studies, the regulatory network and signaling mechanisms that govern biofilm development have been extensively studied ...
resulting in disease outbreaks. The persistence mechanisms of these bacteria remain poorly characterized. It has been proposed that adoption of a biofilm lifestyle allows persistent colonization ...
by a sophisticated, multicomponent regulatory network that responds to environmental conditions, the sensing of host cells, and bacterial density [25]. More than 20 genes encoding transcriptional regulators ...
networks to sense diverse signals that enable it to adapt to different environments and modulate virulence . In this minireview, we explore well-characterized environmental and host cues that S. aureus ...
disease cycle. In this review, we summarise the current knowledge on the infection strategies and regulatory networks controlling virulence and adaptation mechanisms from Xanthomonas species and discuss ...
, by interconnecting the various gene networks [19]. Various regulatory proteins of Xenorhabdus are involved in host interactions, but it has been shown that the fliAZ operon plays a central role in controlling lipase ...
. These examples illustrate that the competition for resources can represent an important selective pressure promoting the evolution towards increased virulence . However, the interaction networks underlying ...
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