Regulation of immune pathways by the NOD-like receptor NLRC5

Regulation of immune pathways by the NOD-like receptor NLRC5 Members of the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family are quickly emerging as critical regulators of innate and adaptive immune responses during microbial infection and autoimmunity. The NLR family member NLRC5 was recently proposed to function as a positive and negative regulator of antiviral immune responses. NLRC5 has also been implicated in regulation of inflammasome signaling and MHC class I transcription. Some of these functions have recently been assessed in NLRC5-deficient mice and immune cells. Here, we summarize and review the newly gained knowledge on the structure, expression profile and putative functions of NLRC5 in regulating immune responses and host defense. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Immunobiology Elsevier

Regulation of immune pathways by the NOD-like receptor NLRC5

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Publisher
Elsevier
Copyright
Copyright © 2011 Elsevier GmbH
ISSN
0171-2985
eISSN
1878-3279
D.O.I.
10.1016/j.imbio.2011.08.011
Publisher site
See Article on Publisher Site

Abstract

Members of the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family are quickly emerging as critical regulators of innate and adaptive immune responses during microbial infection and autoimmunity. The NLR family member NLRC5 was recently proposed to function as a positive and negative regulator of antiviral immune responses. NLRC5 has also been implicated in regulation of inflammasome signaling and MHC class I transcription. Some of these functions have recently been assessed in NLRC5-deficient mice and immune cells. Here, we summarize and review the newly gained knowledge on the structure, expression profile and putative functions of NLRC5 in regulating immune responses and host defense.

Journal

ImmunobiologyElsevier

Published: Jan 1, 2012

References

  • NOD-LRR proteins: role in host–microbial interactions and inflammatory disease
    Inohara; Chamaillard; McDonald, C.; Nunez, G.
  • Nlrp3: an immune sensor of cellular stress and infection
    Lamkanfi, M.; Kanneganti, T.D.

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