Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline, a selective serotonin re-uptake inhibitor

Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline, a... In this paper, we have investigated the regulation of CCK mRNA expression in the brain after restraint stress with and without long-term treatment with the selective serotonin reuptake inhibitor sertraline. Stress alone increases CCK mRNA levels in the hippocampus, whereas no changes were found in the cerebral cortex, amygdaloid complex and thalamus. CCK mRNA expression decreases in the hippocampus, increases in the thalamus and was not modified in the cerebral cortex and amygdaloid complex after sertraline alone. CCK mRNA content was unchanged in all investigated areas after stress plus sertraline compared to control rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline, a selective serotonin re-uptake inhibitor

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Ltd
ISSN
0006-8993
DOI
10.1016/S0006-8993(99)01242-1
Publisher site
See Article on Publisher Site

Abstract

In this paper, we have investigated the regulation of CCK mRNA expression in the brain after restraint stress with and without long-term treatment with the selective serotonin reuptake inhibitor sertraline. Stress alone increases CCK mRNA levels in the hippocampus, whereas no changes were found in the cerebral cortex, amygdaloid complex and thalamus. CCK mRNA expression decreases in the hippocampus, increases in the thalamus and was not modified in the cerebral cortex and amygdaloid complex after sertraline alone. CCK mRNA content was unchanged in all investigated areas after stress plus sertraline compared to control rats.

Journal

Brain ResearchElsevier

Published: Apr 10, 1999

References

  • Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment
    Giardino, L.; Zanni, M.; Bettelli, C.; Savina, M.A.; Calzà, L.
  • The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
    Mongeau, R.; Blier, P.; de Montigny, C.

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